UBE2L3 protein (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

UBE2L3

Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family. (136 aa)

Predicted Functional Partners:

A306_00014317

0.904

A306_00015235

0.899

TSTA3

0.899

RHOT2

0.623

RHOT1

0.623

ATG5

0.573

WRB

0.553

A306_00000364

0.549

SAMM50

0.520

TOMM70

0.499

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000364	RHOT1	A0A2I0LLU5	A0A2I0M7F9	Uncharacterized protein.	Ras homolog family member T1, transcript variant X3.	0.459
A306_00000364	RHOT2	A0A2I0LLU5	A0A2I0LP19	Uncharacterized protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.459
A306_00000364	SAMM50	A0A2I0LLU5	R7VQX7	Uncharacterized protein.	Sorting and assembly machinery component 50 like protein.	0.970
A306_00000364	TOMM70	A0A2I0LLU5	A0A2I0MT18	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.974
A306_00000364	UBE2L3	A0A2I0LLU5	A0A2I0M848	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.549
A306_00014317	UBE2L3	A0A2I0LJ07	A0A2I0M848	Ubiquitin-conjugating enzyme E2-18 kDa.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.904
A306_00015235	TSTA3	A0A2I0LG68	A0A2I0MWS1	GDP-L-fucose synthase.	Tissue specific transplantation antigen P35B.	0.951
A306_00015235	UBE2L3	A0A2I0LG68	A0A2I0M848	GDP-L-fucose synthase.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.899
ATG5	UBE2L3	A0A2I0MTW3	A0A2I0M848	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.573
RHOT1	A306_00000364	A0A2I0M7F9	A0A2I0LLU5	Ras homolog family member T1, transcript variant X3.	Uncharacterized protein.	0.459
RHOT1	TOMM70	A0A2I0M7F9	A0A2I0MT18	Ras homolog family member T1, transcript variant X3.	TPR_REGION domain-containing protein.	0.708
RHOT1	UBE2L3	A0A2I0M7F9	A0A2I0M848	Ras homolog family member T1, transcript variant X3.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.623
RHOT2	A306_00000364	A0A2I0LP19	A0A2I0LLU5	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	Uncharacterized protein.	0.459
RHOT2	TOMM70	A0A2I0LP19	A0A2I0MT18	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	TPR_REGION domain-containing protein.	0.708
RHOT2	UBE2L3	A0A2I0LP19	A0A2I0M848	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.623
SAMM50	A306_00000364	R7VQX7	A0A2I0LLU5	Sorting and assembly machinery component 50 like protein.	Uncharacterized protein.	0.970
SAMM50	TOMM70	R7VQX7	A0A2I0MT18	Sorting and assembly machinery component 50 like protein.	TPR_REGION domain-containing protein.	0.681
SAMM50	UBE2L3	R7VQX7	A0A2I0M848	Sorting and assembly machinery component 50 like protein.	Ubiquitin-conjugating enzyme E2L 3; Belongs to the ubiquitin-conjugating enzyme family.	0.520
TOMM70	A306_00000364	A0A2I0MT18	A0A2I0LLU5	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.974
TOMM70	RHOT1	A0A2I0MT18	A0A2I0M7F9	TPR_REGION domain-containing protein.	Ras homolog family member T1, transcript variant X3.	0.708

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.945

expected number of edges:

16

PPI enrichment p-value:

4.62e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0120255

Olefinic compound biosynthetic process

3 of 14

2.6

2.59

0.00011

GO:0034309

Primary alcohol biosynthetic process

3 of 23

2.38

2.35

0.00021

GO:0042181

Ketone biosynthetic process

3 of 43

2.11

1.91

0.00080

GO:0006351

Transcription, DNA-templated

4 of 201

1.57

1.52

0.00086

GO:0006366

Transcription by RNA polymerase II

3 of 89

1.8

1.47

0.0028

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

3 of 12

2.67

2.94

3.25e-05

GO:0005736

RNA polymerase I complex

2 of 11

2.53

1.71

0.0026

GO:0005666

RNA polymerase III complex

2 of 15

2.39

1.6

0.0036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17413

Olefinic compound biosynthetic process

2 of 5

2.87

1.34

0.0103

CL:3460

RNA polymerase II, core complex

2 of 11

2.53

1.15

0.0192

CL:3359

DNA-directed RNA polymerase complex, and Transcription elongation factor complex

3 of 123

1.66

1.0

0.0192

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 41

2.13

2.27

0.00018

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

3 of 29

2.28

2.14

0.00041

MAP-72086

mRNA Capping

3 of 31

2.25

2.13

0.00041

MAP-113418

Formation of the Early Elongation Complex

3 of 31

2.25

2.13

0.00041

MAP-9018519

Estrogen-dependent gene expression

3 of 37

2.18

2.1

0.00041

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

3 of 39

2.15

2.09

0.00041

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 73

1.88

1.35

0.0058

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 26

2.33

2.58

7.91e-05

KW-0804

Transcription

4 of 208

1.55

1.7

0.00023

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About