ESR2 protein (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ESR2

Estrogen receptor 2 (ER beta). (451 aa)

Predicted Functional Partners:

ESR1

0.934

PGR

0.825

NCOA5

0.809

MED1

0.807

NRIP1

0.790

SP1

0.779

CREBBP

0.767

NCOA1

0.766

NCOA3

0.766

NCOA2

0.766

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	ESR1	A0A2I0M4E3	A0A2I0MUE3	CREB binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.914
CREBBP	ESR2	A0A2I0M4E3	A0A2I0MNB4	CREB binding protein.	Estrogen receptor 2 (ER beta).	0.767
CREBBP	MED1	A0A2I0M4E3	A0A2I0LN50	CREB binding protein.	Mediator complex subunit 1.	0.749
CREBBP	NCOA1	A0A2I0M4E3	A0A2I0LVU4	CREB binding protein.	Nuclear receptor coactivator.	0.800
CREBBP	NCOA2	A0A2I0M4E3	A0A2I0MWY2	CREB binding protein.	Nuclear receptor coactivator 2.	0.800
CREBBP	NCOA3	A0A2I0M4E3	A0A2I0M248	CREB binding protein.	Nuclear receptor coactivator.	0.800
CREBBP	NRIP1	A0A2I0M4E3	A0A2I0MSG1	CREB binding protein.	Nuclear receptor interacting protein 1.	0.621
CREBBP	PGR	A0A2I0M4E3	A0A2I0MCJ9	CREB binding protein.	Progesterone receptor.	0.576
CREBBP	SP1	A0A2I0M4E3	A0A2I0LKC0	CREB binding protein.	Sp1 transcription factor.	0.881
ESR1	CREBBP	A0A2I0MUE3	A0A2I0M4E3	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	CREB binding protein.	0.914
ESR1	ESR2	A0A2I0MUE3	A0A2I0MNB4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2 (ER beta).	0.934
ESR1	MED1	A0A2I0MUE3	A0A2I0LN50	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator complex subunit 1.	0.912
ESR1	NCOA1	A0A2I0MUE3	A0A2I0LVU4	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.833
ESR1	NCOA2	A0A2I0MUE3	A0A2I0MWY2	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator 2.	0.833
ESR1	NCOA3	A0A2I0MUE3	A0A2I0M248	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.833
ESR1	NCOA5	A0A2I0MUE3	A0A2I0M260	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator 5.	0.583
ESR1	NRIP1	A0A2I0MUE3	A0A2I0MSG1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor interacting protein 1.	0.934
ESR1	PGR	A0A2I0MUE3	A0A2I0MCJ9	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Progesterone receptor.	0.943
ESR1	SP1	A0A2I0MUE3	A0A2I0LKC0	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.932
ESR2	CREBBP	A0A2I0MNB4	A0A2I0M4E3	Estrogen receptor 2 (ER beta).	CREB binding protein.	0.767