STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (417 aa)    
Predicted Functional Partners:
PTCH1
Patched 1.
   
 0.918
DISP1
SSD domain-containing protein.
   
 0.887
HHIP
Hedgehog interacting protein.
    
 0.866
CDON
Cell adhesion associated, oncogene regulated.
    
 0.833
A306_00000254
SSD domain-containing protein.
   
 0.825
DISP2
SSD domain-containing protein.
   
 0.807
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.795
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.790
GLI1
GLI family zinc finger 1.
   
 0.789
PTCH2
Uncharacterized protein.
   
 0.772
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.