STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A306_0000146425-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (493 aa)    
Predicted Functional Partners:
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.978
HSD3B7
Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 7, transcript variant X3; Belongs to the 3-beta-HSD family.
   
 0.970
A306_00003679
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family.
   
 0.970
A306_00006782
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
  
 0.966
A306_00013320
Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.
  
  
 0.947
A306_00006461
Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.
  
  
0.919
STS
Steroid sulfatase (Microsomal), isozyme S, transcript variant X1.
     
  0.900
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
  
 0.852
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
   
 0.769
FDFT1
Farnesyl-diphosphate farnesyltransferase 1.
  
 
 0.766
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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