SDZ78974.1 protein (Rubrimonas cliftonensis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SDZ78974.1

acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)

Predicted Functional Partners:

SEA38440.1

0.998

SEB00479.1

0.997

SEA80048.1

0.912

SEA21048.1

0.906

SEB03345.1

0.879

SEA51715.1

0.813

SDZ79395.1

0.797

SDZ78956.1

0.787

SDZ75703.1

0.779

SDZ93494.1

0.779

Your Current Organism:

Rubrimonas cliftonensis

NCBI taxonomy Id: 89524
Other names: CIP 105913, DSM 15345, JCM 10189, NBRC 100047, R. cliftonensis, strain OCh 317

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDZ75703.1	SDZ78974.1	SAMN05444370_101192	SAMN05444370_101361	3-hydroxyisobutyryl-CoA hydrolase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.779
SDZ75703.1	SDZ79395.1	SAMN05444370_101192	SAMN05444370_101381	3-hydroxyisobutyryl-CoA hydrolase.	Enoyl-CoA hydratase.	0.873
SDZ75703.1	SEA21048.1	SAMN05444370_101192	SAMN05444370_103471	3-hydroxyisobutyryl-CoA hydrolase.	Acyl transferase domain-containing protein.	0.917
SDZ75703.1	SEA38440.1	SAMN05444370_101192	SAMN05444370_104338	3-hydroxyisobutyryl-CoA hydrolase.	3-hydroxyacyl-CoA dehydrogenase.	0.658
SDZ75703.1	SEA80048.1	SAMN05444370_101192	SAMN05444370_11251	3-hydroxyisobutyryl-CoA hydrolase.	3-hydroxyacyl-CoA dehydrogenase.	0.619
SDZ75703.1	SEB00479.1	SAMN05444370_101192	SAMN05444370_12810	3-hydroxyisobutyryl-CoA hydrolase.	3-hydroxyacyl-CoA dehydrogenase.	0.608
SDZ78956.1	SDZ78974.1	SAMN05444370_101360	SAMN05444370_101361	3-oxoacyl-[acyl-carrier-protein] reductase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.787
SDZ78956.1	SEA21048.1	SAMN05444370_101360	SAMN05444370_103471	3-oxoacyl-[acyl-carrier-protein] reductase.	Acyl transferase domain-containing protein.	0.794
SDZ78956.1	SEB00479.1	SAMN05444370_101360	SAMN05444370_12810	3-oxoacyl-[acyl-carrier-protein] reductase.	3-hydroxyacyl-CoA dehydrogenase.	0.412
SDZ78974.1	SDZ75703.1	SAMN05444370_101361	SAMN05444370_101192	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyisobutyryl-CoA hydrolase.	0.779
SDZ78974.1	SDZ78956.1	SAMN05444370_101361	SAMN05444370_101360	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-oxoacyl-[acyl-carrier-protein] reductase.	0.787
SDZ78974.1	SDZ79395.1	SAMN05444370_101361	SAMN05444370_101381	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.797
SDZ78974.1	SDZ93494.1	SAMN05444370_101361	SAMN05444370_102242	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.779
SDZ78974.1	SEA21048.1	SAMN05444370_101361	SAMN05444370_103471	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl transferase domain-containing protein.	0.906
SDZ78974.1	SEA38440.1	SAMN05444370_101361	SAMN05444370_104338	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyacyl-CoA dehydrogenase.	0.998
SDZ78974.1	SEA51715.1	SAMN05444370_101361	SAMN05444370_10646	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Indolepyruvate ferredoxin oxidoreductase.	0.813
SDZ78974.1	SEA80048.1	SAMN05444370_101361	SAMN05444370_11251	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyacyl-CoA dehydrogenase.	0.912
SDZ78974.1	SEB00479.1	SAMN05444370_101361	SAMN05444370_12810	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyacyl-CoA dehydrogenase.	0.997
SDZ78974.1	SEB03345.1	SAMN05444370_101361	SAMN05444370_1343	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyacyl-CoA dehydrogenase.	0.879
SDZ79395.1	SDZ75703.1	SAMN05444370_101381	SAMN05444370_101192	Enoyl-CoA hydratase.	3-hydroxyisobutyryl-CoA hydrolase.	0.873

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.676

expected number of edges:

16

PPI enrichment p-value:

0.0223

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

6 of 179

1.86

2.89

1.81e-07

GO:0006351

Transcription, DNA-templated

7 of 313

1.69

2.59

1.81e-07

GO:0006367

Transcription initiation from RNA polymerase II promoter

3 of 33

2.3

1.83

0.00034

GO:0045948

Positive regulation of translational initiation

2 of 19

2.36

1.0

0.0148

GO:0030150

Protein import into mitochondrial matrix

2 of 23

2.28

0.92

0.0199

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 21

2.62

3.24

8.12e-07

GO:0031369

Translation initiation factor binding

2 of 17

2.41

1.0

0.0146

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

5 of 14

2.89

5.66

2.56e-11

GO:0055029

Nuclear DNA-directed RNA polymerase complex

7 of 97

2.2

5.0

9.66e-12

GO:0016591

RNA polymerase II, holoenzyme

6 of 71

2.27

4.73

1.04e-10

GO:0005744

TIM23 mitochondrial import inner membrane translocase complex

2 of 9

2.69

1.65

0.00095

GO:0005654

Nucleoplasm

7 of 2180

0.85

0.7

0.0010

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9495

RNA polymerase II, core complex

5 of 8

3.13

5.64

4.38e-11

CL:9468

RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 181

1.93

3.78

6.36e-10

CL:9476

RNA Polymerase II Pre-transcription Events, and Transcription elongation factor complex

6 of 126

2.02

3.59

8.63e-09

CL:32588

Mitochondrial protein import, and Protein insertion into mitochondrial inner membrane

3 of 38

2.24

1.82

0.00034

CL:32638

TIM23 mitochondrial import inner membrane translocase complex

2 of 5

2.94

1.54

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

6 of 54

2.38

5.25

1.69e-11

map04623

Cytosolic DNA-sensing pathway

2 of 68

1.81

0.71

0.0443

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6803529

FGFR2 alternative splicing

6 of 27

2.69

5.95

3.21e-12

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

6 of 32

2.61

5.83

4.00e-12

MAP-72086

mRNA Capping

6 of 33

2.6

5.81

4.00e-12

MAP-113418

Formation of the Early Elongation Complex

6 of 36

2.56

5.77

4.00e-12

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

6 of 52

2.4

5.21

2.34e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 94

2.21

5.03

9.54e-12

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

6 of 81

2.21

4.39

4.47e-10

GOCC:0005665

RNA polymerase II, core complex

3 of 8

2.91

2.97

3.65e-06

GOCC:0016591

RNA polymerase II, holoenzyme

4 of 59

2.17

2.71

3.65e-06

GOCC:0005744

TIM23 mitochondrial import inner membrane translocase complex

2 of 9

2.69

1.55

0.0015

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

6 of 30

2.64

6.1

1.23e-12

KW-0804

Transcription

7 of 517

1.47

2.18

1.26e-07

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00662

RNA polymerases D

2 of 2

3.34

1.69

0.00092

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