STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoDeoxyribonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (296 aa)    
Predicted Functional Partners:
ExoA
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.869
PepN
Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.796
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.730
AQV02961.2
TIGR02757 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.729
RsbV
Anti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anti-sigma-factor antagonist family.
       0.581
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.541
RsbW
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.528
AQV02449.2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.505
AQV02448.1
ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.485
AQV02405.1
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.451
Your Current Organism:
Desulfococcus multivorans
NCBI taxonomy Id: 897
Other names: ATCC 33890, D. multivorans, DSM 2059, strain 1be1
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