guaA protein (Desulfovibrio piger) - STRING interaction network

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Score

guaA

GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (514 aa)

Predicted Functional Partners:

guaB

0.999

apt

0.987

carB

0.973

gmk

0.958

rdgB

0.956

argS

0.948

hpt

0.945

pyrG

0.944

surE

0.944

purL

0.941

Your Current Organism:

Desulfovibrio piger

NCBI taxonomy Id: 901
Other names: ATCC 29098, D. piger, DSM 749, Desulfomonas pigra

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apt	carB	DESPIGER_1892	DESPIGER_0997	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	0.558
apt	gmk	DESPIGER_1892	DESPIGER_1056	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.958
apt	guaA	DESPIGER_1892	DESPIGER_1027	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.987
apt	guaB	DESPIGER_1892	DESPIGER_1026	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.442
apt	hpt	DESPIGER_1892	DESPIGER_0598	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.935
apt	purL	DESPIGER_1892	DESPIGER_1542	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]	0.735
apt	pyrG	DESPIGER_1892	DESPIGER_0289	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.416
apt	surE	DESPIGER_1892	DESPIGER_1837	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	5-nucleotidase SurE.	0.913
argS	gmk	DESPIGER_1213	DESPIGER_1056	Arginyl-tRNA synthetase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.425
argS	guaA	DESPIGER_1213	DESPIGER_1027	Arginyl-tRNA synthetase.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.948
argS	purL	DESPIGER_1213	DESPIGER_1542	Arginyl-tRNA synthetase.	Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]	0.420
argS	pyrG	DESPIGER_1213	DESPIGER_0289	Arginyl-tRNA synthetase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.758
carB	apt	DESPIGER_0997	DESPIGER_1892	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.558
carB	gmk	DESPIGER_0997	DESPIGER_1056	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.513
carB	guaA	DESPIGER_0997	DESPIGER_1027	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.973
carB	guaB	DESPIGER_0997	DESPIGER_1026	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.828
carB	hpt	DESPIGER_0997	DESPIGER_0598	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.403
carB	purL	DESPIGER_0997	DESPIGER_1542	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]	0.979
carB	pyrG	DESPIGER_0997	DESPIGER_0289	Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.570
gmk	apt	DESPIGER_1056	DESPIGER_1892	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.958