| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SFV72377.1 | trpA | DESPIGER_0489 | DESPIGER_0494 | Anthranilate synthase, aminase component. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.966 |
| SFV72377.1 | trpB | DESPIGER_0489 | DESPIGER_0493 | Anthranilate synthase, aminase component. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.961 |
| SFV72377.1 | trpB-2 | DESPIGER_0489 | DESPIGER_1352 | Anthranilate synthase, aminase component. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.922 |
| SFV72377.1 | trpC | DESPIGER_0489 | DESPIGER_0491 | Anthranilate synthase, aminase component. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
| SFV72377.1 | trpD | DESPIGER_0489 | DESPIGER_0490 | Anthranilate synthase, aminase component. | Anthranilate synthase, amidotransferase component / Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| SFV72377.1 | trpF | DESPIGER_0489 | DESPIGER_0492 | Anthranilate synthase, aminase component. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.989 |
| SFV73485.1 | glyA | DESPIGER_1649 | DESPIGER_1073 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
| SFV73485.1 | ilvA | DESPIGER_1649 | DESPIGER_1171 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
| SFV73485.1 | pssA | DESPIGER_1649 | DESPIGER_1551 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| SFV73485.1 | trpA | DESPIGER_1649 | DESPIGER_0494 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.901 |
| SFV73485.1 | trpB | DESPIGER_1649 | DESPIGER_0493 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| SFV73485.1 | trpB-2 | DESPIGER_1649 | DESPIGER_1352 | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| glyA | SFV73485.1 | DESPIGER_1073 | DESPIGER_1649 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.956 |
| glyA | ilvA | DESPIGER_1073 | DESPIGER_1171 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.927 |
| glyA | pssA | DESPIGER_1073 | DESPIGER_1551 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | trpA | DESPIGER_1073 | DESPIGER_0494 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.928 |
| glyA | trpB | DESPIGER_1073 | DESPIGER_0493 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.910 |
| glyA | trpB-2 | DESPIGER_1073 | DESPIGER_1352 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.910 |
| glyA | trpD | DESPIGER_1073 | DESPIGER_0490 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase, amidotransferase component / Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.439 |
| ilvA | SFV73485.1 | DESPIGER_1171 | DESPIGER_1649 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase, beta subunit / L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.928 |