| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SFV72366.1 | SFV72479.1 | DESPIGER_0478 | DESPIGER_0595 | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.954 |
| SFV72366.1 | ahcY | DESPIGER_0478 | DESPIGER_1953 | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.911 |
| SFV72366.1 | metK | DESPIGER_0478 | DESPIGER_1908 | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.914 |
| SFV72479.1 | SFV72366.1 | DESPIGER_0595 | DESPIGER_0478 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 0.954 |
| SFV72479.1 | SFV74188.1 | DESPIGER_0595 | DESPIGER_2367 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
| SFV72479.1 | ahcY | DESPIGER_0595 | DESPIGER_1953 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.953 |
| SFV72479.1 | glyA | DESPIGER_0595 | DESPIGER_1073 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
| SFV72479.1 | metK | DESPIGER_0595 | DESPIGER_1908 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.953 |
| SFV74188.1 | SFV72479.1 | DESPIGER_2367 | DESPIGER_0595 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.998 |
| SFV74188.1 | glyA | DESPIGER_2367 | DESPIGER_1073 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
| SFV74188.1 | metK | DESPIGER_2367 | DESPIGER_1908 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.690 |
| ahcY | SFV72366.1 | DESPIGER_1953 | DESPIGER_0478 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 0.911 |
| ahcY | SFV72479.1 | DESPIGER_1953 | DESPIGER_0595 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.953 |
| ahcY | glyA | DESPIGER_1953 | DESPIGER_1073 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.420 |
| ahcY | metK | DESPIGER_1953 | DESPIGER_1908 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.758 |
| glyA | SFV72479.1 | DESPIGER_1073 | DESPIGER_0595 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.941 |
| glyA | SFV74188.1 | DESPIGER_1073 | DESPIGER_2367 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
| glyA | ahcY | DESPIGER_1073 | DESPIGER_1953 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.420 |
| glyA | metK | DESPIGER_1073 | DESPIGER_1908 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.675 |
| glyA | purF | DESPIGER_1073 | DESPIGER_1857 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.725 |
