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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mqnEGene SCO4494, often clustered with other genes in menaquinone via futalosine pathway; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (377 aa)    
Predicted Functional Partners:
mqnA
Menaquinone via futalosine step 1; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
  
 0.988
SFV72848.1
Amidohydrolase family protein.
 
  
  0.945
mqnD
Menaquinone via futalosine step 4; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily.
 
   
 0.900
mqnC
Menaquinone via futalosine step 3; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
 
  
0.840
SFV74349.1
Menaquinone via futalosine polyprenyltransferase (MenA homolog); Belongs to the UbiA prenyltransferase family.
 
   
 0.792
SFV73057.1
UbiD family decarboxylase associated with menaquinone via futalosine; Belongs to the UbiD family.
 
   
 0.724
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.633
SFV72847.1
Multi-sensor hybrid histidine kinase.
  
 
 0.587
SFV73908.1
Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).
 
  
 0.543
SFV72275.1
Serine phosphatase RsbU, regulator of sigma subunit.
   
    0.531
Your Current Organism:
Desulfovibrio piger
NCBI taxonomy Id: 901
Other names: ATCC 29098, D. piger, DSM 749, Desulfomonas pigra
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