STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H355_016209DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (619 aa)    
Predicted Functional Partners:
H355_011478
TOP4c domain-containing protein.
 
     0.941
H355_014723
Structural maintenance of chromosomes protein; Belongs to the universal ribosomal protein uL22 family.
   
 
 0.865
H355_013228
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.863
H355_011676
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.840
H355_007969
Uncharacterized protein.
   
  
 0.799
H355_000088
KHA domain-containing protein.
   
 
 0.795
H355_013034
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 
 0.780
H355_010823
Uncharacterized protein.
   
 
 0.767
H355_003736
Uncharacterized protein.
   
  
 0.756
H355_008602
Uncharacterized protein.
   
  
 0.753
Your Current Organism:
Colinus virginianus
NCBI taxonomy Id: 9014
Other names: C. virginianus, bobwhite quail, common bobwhite, northern bobwhite
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.