PIGR protein (Gallus gallus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

PIGR

Ig-like domain-containing protein. (648 aa)

Predicted Functional Partners:

JCHAIN

0.979

PIGA

0.932

VPS26C

0.584

OVSTL

0.558

IL10

0.552

SLC25A44

0.537

NAA25

0.527

CDH1

0.517

SPIA4

0.504

DIP2C

0.501

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH1	IL10	ENSGALP00000000855	ENSGALP00000001310	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.447
CDH1	PIGR	ENSGALP00000000855	ENSGALP00000001351	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	Ig-like domain-containing protein.	0.517
DIP2C	PIGR	ENSGALP00000043816	ENSGALP00000001351	Disco interacting protein 2 homolog C.	Ig-like domain-containing protein.	0.501
IL10	CDH1	ENSGALP00000001310	ENSGALP00000000855	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.447
IL10	PIGR	ENSGALP00000001310	ENSGALP00000001351	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Ig-like domain-containing protein.	0.552
JCHAIN	PIGA	ENSGALP00000018817	ENSGALP00000026670	Uncharacterized protein.	Uncharacterized protein.	0.811
JCHAIN	PIGR	ENSGALP00000018817	ENSGALP00000001351	Uncharacterized protein.	Ig-like domain-containing protein.	0.979
NAA25	PIGR	ENSGALP00000048553	ENSGALP00000001351	TPR_REGION domain-containing protein.	Ig-like domain-containing protein.	0.527
NAA25	SLC25A44	ENSGALP00000048553	ENSGALP00000071058	TPR_REGION domain-containing protein.	Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.533
OVSTL	PIGR	ENSGALP00000051424	ENSGALP00000001351	Uncharacterized protein.	Ig-like domain-containing protein.	0.558
PIGA	JCHAIN	ENSGALP00000026670	ENSGALP00000018817	Uncharacterized protein.	Uncharacterized protein.	0.811
PIGA	PIGR	ENSGALP00000026670	ENSGALP00000001351	Uncharacterized protein.	Ig-like domain-containing protein.	0.932
PIGR	CDH1	ENSGALP00000001351	ENSGALP00000000855	Ig-like domain-containing protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.517
PIGR	DIP2C	ENSGALP00000001351	ENSGALP00000043816	Ig-like domain-containing protein.	Disco interacting protein 2 homolog C.	0.501
PIGR	IL10	ENSGALP00000001351	ENSGALP00000001310	Ig-like domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.552
PIGR	JCHAIN	ENSGALP00000001351	ENSGALP00000018817	Ig-like domain-containing protein.	Uncharacterized protein.	0.979
PIGR	NAA25	ENSGALP00000001351	ENSGALP00000048553	Ig-like domain-containing protein.	TPR_REGION domain-containing protein.	0.527
PIGR	OVSTL	ENSGALP00000001351	ENSGALP00000051424	Ig-like domain-containing protein.	Uncharacterized protein.	0.558
PIGR	PIGA	ENSGALP00000001351	ENSGALP00000026670	Ig-like domain-containing protein.	Uncharacterized protein.	0.932
PIGR	SLC25A44	ENSGALP00000001351	ENSGALP00000071058	Ig-like domain-containing protein.	Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.537