HBEGF protein (Gallus gallus) - STRING interaction network

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Predicted Interactions

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HBEGF

Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)

Predicted Functional Partners:

EGFR

0.989

ERBB4

0.983

EGF

0.936

EREG

0.926

BTC

0.922

ERBB3

0.906

MMP2

0.902

S1PR3

0.750

ERBB2

0.749

EPGN

0.739

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTC	EGF	ENSGALP00000041051	ENSGALP00000044972	Betacellulin.	Uncharacterized protein.	0.856
BTC	EGFR	ENSGALP00000041051	ENSGALP00000053328	Betacellulin.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.962
BTC	EPGN	ENSGALP00000041051	ENSGALP00000017636	Betacellulin.	Epigen; Promotes the growth of epithelial cells.	0.933
BTC	ERBB2	ENSGALP00000041051	ENSGALP00000044764	Betacellulin.	Receptor protein-tyrosine kinase.	0.685
BTC	ERBB3	ENSGALP00000041051	ENSGALP00000051173	Betacellulin.	Protein kinase domain-containing protein.	0.875
BTC	ERBB4	ENSGALP00000041051	ENSGALP00000039169	Betacellulin.	Receptor protein-tyrosine kinase.	0.978
BTC	EREG	ENSGALP00000041051	ENSGALP00000017642	Betacellulin.	EGF-like domain-containing protein.	0.975
BTC	HBEGF	ENSGALP00000041051	ENSGALP00000001399	Betacellulin.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.922
EGF	BTC	ENSGALP00000044972	ENSGALP00000041051	Uncharacterized protein.	Betacellulin.	0.856
EGF	EGFR	ENSGALP00000044972	ENSGALP00000053328	Uncharacterized protein.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.999
EGF	EPGN	ENSGALP00000044972	ENSGALP00000017636	Uncharacterized protein.	Epigen; Promotes the growth of epithelial cells.	0.727
EGF	ERBB2	ENSGALP00000044972	ENSGALP00000044764	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.972
EGF	ERBB3	ENSGALP00000044972	ENSGALP00000051173	Uncharacterized protein.	Protein kinase domain-containing protein.	0.964
EGF	ERBB4	ENSGALP00000044972	ENSGALP00000039169	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.977
EGF	EREG	ENSGALP00000044972	ENSGALP00000017642	Uncharacterized protein.	EGF-like domain-containing protein.	0.881
EGF	HBEGF	ENSGALP00000044972	ENSGALP00000001399	Uncharacterized protein.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.936
EGF	MMP2	ENSGALP00000044972	ENSGALP00000005656	Uncharacterized protein.	72 kDa type IV collagenase; Belongs to the peptidase M10A family.	0.449
EGFR	BTC	ENSGALP00000053328	ENSGALP00000041051	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	Betacellulin.	0.962
EGFR	EGF	ENSGALP00000053328	ENSGALP00000044972	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	Uncharacterized protein.	0.999
EGFR	EPGN	ENSGALP00000053328	ENSGALP00000017636	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	Epigen; Promotes the growth of epithelial cells.	0.825

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