HERPUD1 protein (Gallus gallus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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[Homology]

Score

HERPUD1

Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)

Predicted Functional Partners:

DNAJB9

0.686

XBP1

0.669

DERL2

0.640

ATF4

0.616

MANF

0.607

SVIP

0.588

DNAJC3

0.587

HSPA5

0.582

ATF6

0.582

DERL3

0.542

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	ATF6	ENSGALP00000037099	ENSGALP00000043808	ATF4.	Activating transcription factor 6.	0.938
ATF4	DNAJB9	ENSGALP00000037099	ENSGALP00000071753	ATF4.	J domain-containing protein.	0.512
ATF4	HERPUD1	ENSGALP00000037099	ENSGALP00000001850	ATF4.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.616
ATF4	HSPA5	ENSGALP00000037099	ENSGALP00000001474	ATF4.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.846
ATF4	XBP1	ENSGALP00000037099	ENSGALP00000009296	ATF4.	BZIP domain-containing protein.	0.954
ATF6	ATF4	ENSGALP00000043808	ENSGALP00000037099	Activating transcription factor 6.	ATF4.	0.938
ATF6	DERL2	ENSGALP00000043808	ENSGALP00000057135	Activating transcription factor 6.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.475
ATF6	DNAJB9	ENSGALP00000043808	ENSGALP00000071753	Activating transcription factor 6.	J domain-containing protein.	0.574
ATF6	DNAJC3	ENSGALP00000043808	ENSGALP00000027249	Activating transcription factor 6.	DnaJ homolog subfamily C member 3; May be involved in the unfolded protein response (UPR) during ER stress.	0.548
ATF6	HERPUD1	ENSGALP00000043808	ENSGALP00000001850	Activating transcription factor 6.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.582
ATF6	HSPA5	ENSGALP00000043808	ENSGALP00000001474	Activating transcription factor 6.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.983
ATF6	MANF	ENSGALP00000043808	ENSGALP00000067347	Activating transcription factor 6.	Mesencephalic astrocyte derived neurotrophic factor.	0.531
ATF6	XBP1	ENSGALP00000043808	ENSGALP00000009296	Activating transcription factor 6.	BZIP domain-containing protein.	0.993
DERL2	ATF6	ENSGALP00000057135	ENSGALP00000043808	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Activating transcription factor 6.	0.475
DERL2	DERL3	ENSGALP00000057135	ENSGALP00000059664	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.725
DERL2	DNAJC3	ENSGALP00000057135	ENSGALP00000027249	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ homolog subfamily C member 3; May be involved in the unfolded protein response (UPR) during ER stress.	0.491
DERL2	HERPUD1	ENSGALP00000057135	ENSGALP00000001850	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.640
DERL2	HSPA5	ENSGALP00000057135	ENSGALP00000001474	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.758
DERL2	XBP1	ENSGALP00000057135	ENSGALP00000009296	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	BZIP domain-containing protein.	0.516
DERL3	DERL2	ENSGALP00000059664	ENSGALP00000057135	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.725