STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)    
Predicted Functional Partners:
STAT1
Signal transducer and activator of transcription.
   
 
 0.953
MDM2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
   
 0.927
STAT2
Signal transducer and activator of transcription.
   
 
 0.907
TLR3
Toll-like receptor 3; Belongs to the Toll-like receptor family.
   
  
 0.880
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 
 0.862
IFNA3
Interferon.
      
 0.846
IFIH1
Uncharacterized protein.
   
 
 0.839
STAT3
Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.
   
 
 0.827
IFIT5
Uncharacterized protein.
   
 
 0.825
SOCS1
Suppressor of cytokine signaling 1.
   
 
 0.824
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.