STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR5A2Nuclear receptor subfamily 5 group A member 2; Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism (By similarity). Activates the transcription of CYP2C38 (By similarity). (541 aa)    
Predicted Functional Partners:
NCOA3
Nuclear receptor coactivator.
    
 0.886
ZNF217L
Uncharacterized protein.
   
  0.803
NR0B2
NR LBD domain-containing protein.
   
 
0.797
NR0B1
NR LBD domain-containing protein.
   
 
0.777
CTNNB1
Uncharacterized protein.
    
 
 0.710
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
   
0.679
PPARGC1A
RRM domain-containing protein.
    
 
 0.659
HOXB7
Homeobox B7.
    
 
 0.646
JUP
Plakoglobin.
    
 
 0.595
GATA6
Transcription factor GATA-6; Transcriptional activator.
   
 
 0.577
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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