STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADPRHL2ADP-ribose glycohydrolase ARH3; ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP- ribosylation of proteins constitutes the primary form of ADP- ribosylation of proteins i [...] (367 aa)    
Predicted Functional Partners:
OARD1
Macro domain-containing protein.
      
 0.951
PARG
Poly(ADP-ribose) glycohydrolase.
      
 0.872
PARP3
Poly [ADP-ribose] polymerase.
    
 
 0.845
TRPM2
Transient receptor potential cation channel subfamily M member 2.
      
 0.742
PARP4
Poly [ADP-ribose] polymerase.
    
 
 0.708
TERF1
Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
      
 0.704
PARP16
Poly [ADP-ribose] polymerase.
      
 0.678
MACROD2
Uncharacterized protein.
      
 0.675
TNKS
Poly [ADP-ribose] polymerase.
   
 
 0.618
PARP6
Poly [ADP-ribose] polymerase.
   
 
 0.611
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.