node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | POMC | ENSGALP00000070787 | ENSGALP00000063133 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Uncharacterized protein. | 0.786 |
CGA | POU1F1 | ENSGALP00000070787 | ENSGALP00000045301 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. | 0.466 |
CGA | PRL | ENSGALP00000070787 | ENSGALP00000020651 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Prolactin. | 0.534 |
CGA | TSHB-2 | ENSGALP00000070787 | ENSGALP00000004015 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.995 |
CGA | TSHR | ENSGALP00000070787 | ENSGALP00000017185 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.871 |
DIO2 | TRH | ENSGALP00000068702 | ENSGALP00000013820 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. | 0.559 |
DIO2 | TSHB-2 | ENSGALP00000068702 | ENSGALP00000004015 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.741 |
DIO2 | TSHR | ENSGALP00000068702 | ENSGALP00000017185 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.747 |
EYA3 | LOC417800 | ENSGALP00000001125 | ENSGALP00000015633 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | Uncharacterized protein. | 0.419 |
EYA3 | POU1F1 | ENSGALP00000001125 | ENSGALP00000045301 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. | 0.605 |
EYA3 | PRL | ENSGALP00000001125 | ENSGALP00000020651 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | Prolactin. | 0.408 |
EYA3 | TSHB-2 | ENSGALP00000001125 | ENSGALP00000004015 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.796 |
EYA3 | TSHR | ENSGALP00000001125 | ENSGALP00000017185 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.782 |
LOC417800 | EYA3 | ENSGALP00000015633 | ENSGALP00000001125 | Uncharacterized protein. | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] | 0.419 |
LOC417800 | POMC | ENSGALP00000015633 | ENSGALP00000063133 | Uncharacterized protein. | Uncharacterized protein. | 0.841 |
LOC417800 | POU1F1 | ENSGALP00000015633 | ENSGALP00000045301 | Uncharacterized protein. | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. | 0.790 |
LOC417800 | PRL | ENSGALP00000015633 | ENSGALP00000020651 | Uncharacterized protein. | Prolactin. | 0.943 |
LOC417800 | TRH | ENSGALP00000015633 | ENSGALP00000013820 | Uncharacterized protein. | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. | 0.808 |
LOC417800 | TSHB-2 | ENSGALP00000015633 | ENSGALP00000004015 | Uncharacterized protein. | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. | 0.786 |
POMC | CGA | ENSGALP00000063133 | ENSGALP00000070787 | Uncharacterized protein. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.786 |