node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASS | ODC1 | ENSGALP00000055236 | ENSGALP00000026476 | Aminoadipate-semialdehyde synthase. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.762 |
AASS | SRM | ENSGALP00000055236 | ENSGALP00000004799 | Aminoadipate-semialdehyde synthase. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.928 |
AGMAT | AMD1 | ENSGALP00000049981 | ENSGALP00000058593 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | S-adenosylmethionine decarboxylase proenzyme. | 0.633 |
AGMAT | AOC1 | ENSGALP00000049981 | ENSGALP00000052339 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Amine oxidase. | 0.944 |
AGMAT | ARG2 | ENSGALP00000049981 | ENSGALP00000015485 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Arginase. | 0.609 |
AGMAT | ODC1 | ENSGALP00000049981 | ENSGALP00000026476 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.979 |
AGMAT | SAT1 | ENSGALP00000049981 | ENSGALP00000035846 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells (By similarity); Belongs to the acetyltransferase family. | 0.952 |
AGMAT | SMOX | ENSGALP00000049981 | ENSGALP00000025700 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermine oxidase. | 0.500 |
AGMAT | SMS | ENSGALP00000049981 | ENSGALP00000035844 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | PABS domain-containing protein. | 0.886 |
AGMAT | SRM | ENSGALP00000049981 | ENSGALP00000004799 | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.987 |
AMD1 | AGMAT | ENSGALP00000058593 | ENSGALP00000049981 | S-adenosylmethionine decarboxylase proenzyme. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.633 |
AMD1 | ARG2 | ENSGALP00000058593 | ENSGALP00000015485 | S-adenosylmethionine decarboxylase proenzyme. | Arginase. | 0.849 |
AMD1 | MTAP | ENSGALP00000058593 | ENSGALP00000013273 | S-adenosylmethionine decarboxylase proenzyme. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.605 |
AMD1 | ODC1 | ENSGALP00000058593 | ENSGALP00000026476 | S-adenosylmethionine decarboxylase proenzyme. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.872 |
AMD1 | SAT1 | ENSGALP00000058593 | ENSGALP00000035846 | S-adenosylmethionine decarboxylase proenzyme. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells (By similarity); Belongs to the acetyltransferase family. | 0.650 |
AMD1 | SMOX | ENSGALP00000058593 | ENSGALP00000025700 | S-adenosylmethionine decarboxylase proenzyme. | Spermine oxidase. | 0.838 |
AMD1 | SMS | ENSGALP00000058593 | ENSGALP00000035844 | S-adenosylmethionine decarboxylase proenzyme. | PABS domain-containing protein. | 0.998 |
AMD1 | SRM | ENSGALP00000058593 | ENSGALP00000004799 | S-adenosylmethionine decarboxylase proenzyme. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.998 |
AOC1 | AGMAT | ENSGALP00000052339 | ENSGALP00000049981 | Amine oxidase. | Agmatinase, mitochondrial; Belongs to the arginase family. Agmatinase subfamily. | 0.944 |
AOC1 | ODC1 | ENSGALP00000052339 | ENSGALP00000026476 | Amine oxidase. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.927 |