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RPA1 protein (Gallus gallus) - STRING interaction network
"RPA1" - Replication protein A 70 kDa DNA-binding subunit in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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RPA1Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (614 aa)    
Predicted Functional Partners:
RPA2
Gallus gallus replication protein A2, 32kDa (RPA2), mRNA (267 aa)
     
  0.998
RPA3
Replication protein A3, 14kDa (121 aa)
     
  0.997
MCM2
DNA helicase; Gallus gallus minichromosome maintenance complex component 2 (MCM2), mRNA; Belongs to the MCM family (888 aa)
     
  0.997
MCM6
DNA helicase; Gallus gallus minichromosome maintenance complex component 6 (MCM6), mRNA; Belongs to the MCM family (915 aa)
     
  0.997
BLM
Bloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3’-5’ direction. Participates in DNA replication and repair (By similarity). Involved in 5’-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single- stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity); Belongs to the helicase family. R [...] (1380 aa)
     
  0.996
MCM4
DNA helicase; Minichromosome maintenance complex component 4; Belongs to the MCM family (859 aa)
     
  0.996
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family (262 aa)
     
  0.996
FANCM
Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movab [...] (1971 aa)
     
  0.995
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (1020 aa)
     
  0.994
WRN
Werner syndrome, RecQ helicase-like (1497 aa)
     
  0.993
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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