node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL1 | FBXL8 | ENSGALP00000046909 | ENSGALP00000005061 | Cullin 1; Belongs to the cullin family. | F-box domain-containing protein. | 0.692 |
CUL1 | NEDD8 | ENSGALP00000046909 | ENSGALP00000055513 | Cullin 1; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.998 |
CUL1 | SKP1 | ENSGALP00000046909 | ENSGALP00000010447 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). | 0.999 |
CUL1 | TCEB1 | ENSGALP00000046909 | ENSGALP00000055188 | Cullin 1; Belongs to the cullin family. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.882 |
FBXL8 | CUL1 | ENSGALP00000005061 | ENSGALP00000046909 | F-box domain-containing protein. | Cullin 1; Belongs to the cullin family. | 0.692 |
FBXL8 | HSF1 | ENSGALP00000005061 | ENSGALP00000057858 | F-box domain-containing protein. | Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] | 0.763 |
FBXL8 | HSF2 | ENSGALP00000005061 | ENSGALP00000068068 | F-box domain-containing protein. | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. | 0.770 |
FBXL8 | HSF4 | ENSGALP00000005061 | ENSGALP00000005096 | F-box domain-containing protein. | HSF_DOMAIN domain-containing protein. | 0.823 |
FBXL8 | MIPOL1 | ENSGALP00000005061 | ENSGALP00000016440 | F-box domain-containing protein. | Mirror-image polydactyly 1. | 0.571 |
FBXL8 | NEDD8 | ENSGALP00000005061 | ENSGALP00000055513 | F-box domain-containing protein. | NEDD8 ubiquitin like modifier. | 0.579 |
FBXL8 | PROM2 | ENSGALP00000005061 | ENSGALP00000054919 | F-box domain-containing protein. | Prominin 2. | 0.586 |
FBXL8 | SKP1 | ENSGALP00000005061 | ENSGALP00000010447 | F-box domain-containing protein. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). | 0.775 |
FBXL8 | TCEB1 | ENSGALP00000005061 | ENSGALP00000055188 | F-box domain-containing protein. | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. | 0.596 |
FBXL8 | TMEM208 | ENSGALP00000005061 | ENSGALP00000053597 | F-box domain-containing protein. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy; Belongs to the TMEM208 family. | 0.625 |
HSF1 | FBXL8 | ENSGALP00000057858 | ENSGALP00000005061 | Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] | F-box domain-containing protein. | 0.763 |
HSF1 | HSF2 | ENSGALP00000057858 | ENSGALP00000068068 | Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. | 0.487 |
HSF1 | PROM2 | ENSGALP00000057858 | ENSGALP00000054919 | Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] | Prominin 2. | 0.534 |
HSF2 | FBXL8 | ENSGALP00000068068 | ENSGALP00000005061 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. | F-box domain-containing protein. | 0.770 |
HSF2 | HSF1 | ENSGALP00000068068 | ENSGALP00000057858 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. | Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] | 0.487 |
HSF2 | HSF4 | ENSGALP00000068068 | ENSGALP00000005096 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. | HSF_DOMAIN domain-containing protein. | 0.706 |