node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EP300 | FOXO1 | ENSGALP00000019537 | ENSGALP00000056572 | E1A binding protein p300. | Fork-head domain-containing protein. | 0.530 |
EP300 | STAT1 | ENSGALP00000019537 | ENSGALP00000046362 | E1A binding protein p300. | Signal transducer and activator of transcription. | 0.626 |
EP300 | STAT3 | ENSGALP00000019537 | ENSGALP00000005161 | E1A binding protein p300. | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. | 0.969 |
FOXO1 | EP300 | ENSGALP00000056572 | ENSGALP00000019537 | Fork-head domain-containing protein. | E1A binding protein p300. | 0.530 |
FOXO1 | IL6 | ENSGALP00000056572 | ENSGALP00000068117 | Fork-head domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | 0.541 |
FOXO1 | STAT1 | ENSGALP00000056572 | ENSGALP00000046362 | Fork-head domain-containing protein. | Signal transducer and activator of transcription. | 0.418 |
FOXO1 | STAT3 | ENSGALP00000056572 | ENSGALP00000005161 | Fork-head domain-containing protein. | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. | 0.962 |
FOXO1 | STAT5A | ENSGALP00000056572 | ENSGALP00000005182 | Fork-head domain-containing protein. | Signal transducer and activator of transcription. | 0.490 |
IL6 | FOXO1 | ENSGALP00000068117 | ENSGALP00000056572 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Fork-head domain-containing protein. | 0.541 |
IL6 | JAK1 | ENSGALP00000068117 | ENSGALP00000017948 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Tyrosine-protein kinase. | 0.917 |
IL6 | JAK2 | ENSGALP00000068117 | ENSGALP00000074116 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.908 |
IL6 | SOCS3 | ENSGALP00000068117 | ENSGALP00000042295 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] | 0.910 |
IL6 | SRC | ENSGALP00000068117 | ENSGALP00000006117 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.716 |
IL6 | STAT1 | ENSGALP00000068117 | ENSGALP00000046362 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Signal transducer and activator of transcription. | 0.929 |
IL6 | STAT3 | ENSGALP00000068117 | ENSGALP00000005161 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. | 0.988 |
IL6 | STAT5A | ENSGALP00000068117 | ENSGALP00000005182 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Signal transducer and activator of transcription. | 0.773 |
IL6 | TYK2 | ENSGALP00000068117 | ENSGALP00000053236 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | Tyrosine-protein kinase. | 0.886 |
JAK1 | IL6 | ENSGALP00000017948 | ENSGALP00000068117 | Tyrosine-protein kinase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | 0.917 |
JAK1 | JAK2 | ENSGALP00000017948 | ENSGALP00000074116 | Tyrosine-protein kinase. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.960 |
JAK1 | SOCS3 | ENSGALP00000017948 | ENSGALP00000042295 | Tyrosine-protein kinase. | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] | 0.986 |