node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APC | KHDRBS1 | ENSGALP00000050374 | ENSGALP00000053054 | APC regulator of WNT signaling pathway. | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] | 0.683 |
GRB2 | KHDRBS1 | ENSGALP00000012993 | ENSGALP00000053054 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] | 0.726 |
GRB2 | SRC | ENSGALP00000012993 | ENSGALP00000006117 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.911 |
HNRNPA1 | HNRNPK | ENSGALP00000047929 | ENSGALP00000020534 | Uncharacterized protein. | Heterogeneous nuclear ribonucleoprotein K. | 0.907 |
HNRNPA1 | HNRNPKL | ENSGALP00000047929 | ENSGALP00000061636 | Uncharacterized protein. | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). | 0.907 |
HNRNPA1 | HNRNPM | ENSGALP00000047929 | ENSGALP00000000509 | Uncharacterized protein. | Uncharacterized protein. | 0.781 |
HNRNPA1 | KHDRBS1 | ENSGALP00000047929 | ENSGALP00000053054 | Uncharacterized protein. | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] | 0.814 |
HNRNPA1 | SRSF1 | ENSGALP00000047929 | ENSGALP00000038262 | Uncharacterized protein. | Serine/arginine-rich splicing factor 1; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. | 0.926 |
HNRNPA1 | SRSF2 | ENSGALP00000047929 | ENSGALP00000056912 | Uncharacterized protein. | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. | 0.835 |
HNRNPA1 | U2AF2 | ENSGALP00000047929 | ENSGALP00000070353 | Uncharacterized protein. | U2 small nuclear RNA auxiliary factor 2. | 0.520 |
HNRNPK | HNRNPA1 | ENSGALP00000020534 | ENSGALP00000047929 | Heterogeneous nuclear ribonucleoprotein K. | Uncharacterized protein. | 0.907 |
HNRNPK | HNRNPKL | ENSGALP00000020534 | ENSGALP00000061636 | Heterogeneous nuclear ribonucleoprotein K. | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). | 0.900 |
HNRNPK | HNRNPM | ENSGALP00000020534 | ENSGALP00000000509 | Heterogeneous nuclear ribonucleoprotein K. | Uncharacterized protein. | 0.980 |
HNRNPK | KHDRBS1 | ENSGALP00000020534 | ENSGALP00000053054 | Heterogeneous nuclear ribonucleoprotein K. | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] | 0.845 |
HNRNPK | SRSF1 | ENSGALP00000020534 | ENSGALP00000038262 | Heterogeneous nuclear ribonucleoprotein K. | Serine/arginine-rich splicing factor 1; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. | 0.905 |
HNRNPK | SRSF2 | ENSGALP00000020534 | ENSGALP00000056912 | Heterogeneous nuclear ribonucleoprotein K. | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. | 0.844 |
HNRNPK | U2AF2 | ENSGALP00000020534 | ENSGALP00000070353 | Heterogeneous nuclear ribonucleoprotein K. | U2 small nuclear RNA auxiliary factor 2. | 0.664 |
HNRNPKL | HNRNPA1 | ENSGALP00000061636 | ENSGALP00000047929 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). | Uncharacterized protein. | 0.907 |
HNRNPKL | HNRNPK | ENSGALP00000061636 | ENSGALP00000020534 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). | Heterogeneous nuclear ribonucleoprotein K. | 0.900 |
HNRNPKL | HNRNPM | ENSGALP00000061636 | ENSGALP00000000509 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). | Uncharacterized protein. | 0.979 |