node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | CD44 | ENSGALP00000060844 | ENSGALP00000056897 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Link domain-containing protein. | 0.787 |
ACTB | COL3A1 | ENSGALP00000060844 | ENSGALP00000051057 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.984 |
ACTB | DCN | ENSGALP00000060844 | ENSGALP00000062069 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.567 |
ACTB | MMP2 | ENSGALP00000060844 | ENSGALP00000005656 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 72 kDa type IV collagenase; Belongs to the peptidase M10A family. | 0.779 |
ACTB | TGFB1 | ENSGALP00000060844 | ENSGALP00000053940 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.845 |
ACTB | TIMP2 | ENSGALP00000060844 | ENSGALP00000041954 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. | 0.488 |
ACTB | TIMP3 | ENSGALP00000060844 | ENSGALP00000040866 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. | 0.410 |
CD44 | ACTB | ENSGALP00000056897 | ENSGALP00000060844 | Link domain-containing protein. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.787 |
CD44 | COL3A1 | ENSGALP00000056897 | ENSGALP00000051057 | Link domain-containing protein. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.908 |
CD44 | DCN | ENSGALP00000056897 | ENSGALP00000062069 | Link domain-containing protein. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.411 |
CD44 | HBEGF | ENSGALP00000056897 | ENSGALP00000001399 | Link domain-containing protein. | Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] | 0.724 |
CD44 | MMP2 | ENSGALP00000056897 | ENSGALP00000005656 | Link domain-containing protein. | 72 kDa type IV collagenase; Belongs to the peptidase M10A family. | 0.741 |
CD44 | TGFB1 | ENSGALP00000056897 | ENSGALP00000053940 | Link domain-containing protein. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.728 |
CD44 | TIMP2 | ENSGALP00000056897 | ENSGALP00000041954 | Link domain-containing protein. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. | 0.448 |
COL3A1 | ACTB | ENSGALP00000051057 | ENSGALP00000060844 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.984 |
COL3A1 | CD44 | ENSGALP00000051057 | ENSGALP00000056897 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Link domain-containing protein. | 0.908 |
COL3A1 | DCN | ENSGALP00000051057 | ENSGALP00000062069 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.985 |
COL3A1 | HBEGF | ENSGALP00000051057 | ENSGALP00000001399 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] | 0.473 |
COL3A1 | MMP2 | ENSGALP00000051057 | ENSGALP00000005656 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 72 kDa type IV collagenase; Belongs to the peptidase M10A family. | 0.919 |
COL3A1 | OPTC | ENSGALP00000051057 | ENSGALP00000056729 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | LRRNT domain-containing protein. | 0.542 |