node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL1 | CUL5 | ENSGALP00000046909 | ENSGALP00000045443 | Cullin 1; Belongs to the cullin family. | Cullin 5; Belongs to the cullin family. | 0.847 |
CUL1 | DCUN1D3 | ENSGALP00000046909 | ENSGALP00000044602 | Cullin 1; Belongs to the cullin family. | Defective in cullin neddylation 1 domain containing 3. | 0.825 |
CUL1 | NAE1 | ENSGALP00000046909 | ENSGALP00000050474 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). | 0.884 |
CUL1 | NEDD8 | ENSGALP00000046909 | ENSGALP00000055513 | Cullin 1; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.998 |
CUL1 | RBX1 | ENSGALP00000046909 | ENSGALP00000019539 | Cullin 1; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL1 | RNF7 | ENSGALP00000046909 | ENSGALP00000033343 | Cullin 1; Belongs to the cullin family. | RING-type domain-containing protein. | 0.849 |
CUL1 | UBA3 | ENSGALP00000046909 | ENSGALP00000052128 | Cullin 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.920 |
CUL1 | UBE2F | ENSGALP00000046909 | ENSGALP00000064619 | Cullin 1; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.851 |
CUL5 | CUL1 | ENSGALP00000045443 | ENSGALP00000046909 | Cullin 5; Belongs to the cullin family. | Cullin 1; Belongs to the cullin family. | 0.847 |
CUL5 | DCUN1D3 | ENSGALP00000045443 | ENSGALP00000044602 | Cullin 5; Belongs to the cullin family. | Defective in cullin neddylation 1 domain containing 3. | 0.737 |
CUL5 | NAE1 | ENSGALP00000045443 | ENSGALP00000050474 | Cullin 5; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). | 0.637 |
CUL5 | NEDD8 | ENSGALP00000045443 | ENSGALP00000055513 | Cullin 5; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.993 |
CUL5 | RBX1 | ENSGALP00000045443 | ENSGALP00000019539 | Cullin 5; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL5 | RNF7 | ENSGALP00000045443 | ENSGALP00000033343 | Cullin 5; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL5 | UBA3 | ENSGALP00000045443 | ENSGALP00000052128 | Cullin 5; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.780 |
CUL5 | UBE2F | ENSGALP00000045443 | ENSGALP00000064619 | Cullin 5; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.875 |
DCUN1D3 | CUL1 | ENSGALP00000044602 | ENSGALP00000046909 | Defective in cullin neddylation 1 domain containing 3. | Cullin 1; Belongs to the cullin family. | 0.825 |
DCUN1D3 | CUL5 | ENSGALP00000044602 | ENSGALP00000045443 | Defective in cullin neddylation 1 domain containing 3. | Cullin 5; Belongs to the cullin family. | 0.737 |
DCUN1D3 | NAE1 | ENSGALP00000044602 | ENSGALP00000050474 | Defective in cullin neddylation 1 domain containing 3. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). | 0.615 |
DCUN1D3 | NEDD8 | ENSGALP00000044602 | ENSGALP00000055513 | Defective in cullin neddylation 1 domain containing 3. | NEDD8 ubiquitin like modifier. | 0.783 |