node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID4A | HDAC4 | ENSGALP00000000021 | ENSGALP00000033098 | ARID domain-containing protein. | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.674 |
ARID4A | SIN3A | ENSGALP00000000021 | ENSGALP00000002508 | ARID domain-containing protein. | HDAC_interact domain-containing protein. | 0.990 |
CAMK4 | CAMK4L | ENSGALP00000063204 | ENSGALP00000072270 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.900 |
CAMK4 | HDAC4 | ENSGALP00000063204 | ENSGALP00000033098 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.903 |
CAMK4L | CAMK4 | ENSGALP00000072270 | ENSGALP00000063204 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.900 |
CAMK4L | HDAC4 | ENSGALP00000072270 | ENSGALP00000033098 | Protein kinase domain-containing protein. | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.903 |
CCND1 | HDAC4 | ENSGALP00000012203 | ENSGALP00000033098 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.729 |
CCND1 | SIRT1 | ENSGALP00000012203 | ENSGALP00000004350 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Deacetylase sirtuin-type domain-containing protein. | 0.580 |
CCND1 | SMAD3 | ENSGALP00000012203 | ENSGALP00000058076 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). | 0.566 |
HDAC4 | ARID4A | ENSGALP00000033098 | ENSGALP00000000021 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | ARID domain-containing protein. | 0.674 |
HDAC4 | CAMK4 | ENSGALP00000033098 | ENSGALP00000063204 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.903 |
HDAC4 | CAMK4L | ENSGALP00000033098 | ENSGALP00000072270 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Protein kinase domain-containing protein. | 0.903 |
HDAC4 | CCND1 | ENSGALP00000033098 | ENSGALP00000012203 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). | 0.729 |
HDAC4 | NCOR2 | ENSGALP00000033098 | ENSGALP00000073350 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Nuclear receptor corepressor 2. | 0.685 |
HDAC4 | NUP155 | ENSGALP00000033098 | ENSGALP00000005832 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Nucleoporin 155. | 0.772 |
HDAC4 | SIN3A | ENSGALP00000033098 | ENSGALP00000002508 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | HDAC_interact domain-containing protein. | 0.748 |
HDAC4 | SIRT1 | ENSGALP00000033098 | ENSGALP00000004350 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Deacetylase sirtuin-type domain-containing protein. | 0.817 |
HDAC4 | SMAD3 | ENSGALP00000033098 | ENSGALP00000058076 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). | 0.752 |
HDAC4 | UBE2I | ENSGALP00000033098 | ENSGALP00000010363 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.700 |
NCOR2 | HDAC4 | ENSGALP00000073350 | ENSGALP00000033098 | Nuclear receptor corepressor 2. | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.685 |