node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHH | DISP3 | ENSGALP00000054006 | ENSGALP00000007415 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | 0.700 |
DHH | IHH | ENSGALP00000054006 | ENSGALP00000018493 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.906 |
DHH | SHH | ENSGALP00000054006 | ENSGALP00000010292 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.905 |
DISP3 | DHH | ENSGALP00000007415 | ENSGALP00000054006 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.700 |
DISP3 | DNAAF2 | ENSGALP00000007415 | ENSGALP00000019948 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. | 0.701 |
DISP3 | FBXO2 | ENSGALP00000007415 | ENSGALP00000054218 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | F-box protein 2. | 0.674 |
DISP3 | IHH | ENSGALP00000007415 | ENSGALP00000018493 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.707 |
DISP3 | PLEKHA7 | ENSGALP00000007415 | ENSGALP00000065938 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Pleckstrin homology domain containing A7. | 0.666 |
DISP3 | PTCHD1 | ENSGALP00000007415 | ENSGALP00000026339 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Patched domain containing 1. | 0.727 |
DISP3 | PTCHD4 | ENSGALP00000007415 | ENSGALP00000026940 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | SSD domain-containing protein. | 0.799 |
DISP3 | SHH | ENSGALP00000007415 | ENSGALP00000010292 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.737 |
DISP3 | UBIAD1 | ENSGALP00000007415 | ENSGALP00000005301 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] | 0.617 |
DISP3 | ZNF536 | ENSGALP00000007415 | ENSGALP00000072602 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | Zinc finger protein 536. | 0.627 |
DNAAF2 | DISP3 | ENSGALP00000019948 | ENSGALP00000007415 | Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | 0.701 |
DNAAF2 | PLEKHA7 | ENSGALP00000019948 | ENSGALP00000065938 | Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. | Pleckstrin homology domain containing A7. | 0.741 |
FBXO2 | DISP3 | ENSGALP00000054218 | ENSGALP00000007415 | F-box protein 2. | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | 0.674 |
FBXO2 | UBIAD1 | ENSGALP00000054218 | ENSGALP00000005301 | F-box protein 2. | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] | 0.429 |
FBXO2 | ZNF536 | ENSGALP00000054218 | ENSGALP00000072602 | F-box protein 2. | Zinc finger protein 536. | 0.590 |
IHH | DHH | ENSGALP00000018493 | ENSGALP00000054006 | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.906 |
IHH | DISP3 | ENSGALP00000018493 | ENSGALP00000007415 | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. | 0.707 |