STRINGSTRING
RAF1 protein (Gallus gallus) - STRING interaction network
"RAF1" - RAF proto-oncogene serine/threonine-protein kinase in Gallus gallus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAF1RAF proto-oncogene serine/threonine-protein kinase ; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity) (647 aa)    
Predicted Functional Partners:
RAP1B
Ras-related protein Rap-1b ; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity) (184 aa)
     
  0.996
RAP1A
Uncharacterized protein (188 aa)
     
  0.996
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1 (395 aa)
     
0.994
HRAS
GTPase HRas ; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
     
  0.992
NRAS
GTPase NRas ; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (193 aa)
     
  0.992
KRAS
Uncharacterized protein (188 aa)
     
  0.992
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2 ; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) (398 aa)
     
0.990
YWHAZ
14-3-3 protein zeta ; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity) (245 aa)
     
  0.976
YWHAB
14-3-3 protein beta/alpha ; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity) (244 aa)
     
  0.976
MAPK1
Mitogen-activated protein kinase 1 (321 aa)
     
0.967
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus, Gallus domesticus, Gallus gallus, Gallus gallus domesticus, Phasianinae, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (33%) [HD]