Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
GUCY1B4Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (732 aa)    
Predicted Functional Partners:
GUCY1A1
Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
   
 
 0.976
PRKG2
cGMP-dependent protein kinase.
  
 0.914
PRKG1
Uncharacterized protein; Belongs to the protein kinase superfamily.
  
 0.914
ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase 3.
     
 0.910
ENPP1
Uncharacterized protein.
     
 0.905
NUDT2
Nudix hydrolase 2.
     
  0.900
PDE5A
Phosphodiesterase.
   
 0.868
GCH1
GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family.
     
 0.807
MOCS1
Molybdenum cofactor synthesis 1.
   
 
  0.801
PDE11A
Phosphodiesterase.
   
 0.778
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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