node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP17A1 | CYP19A1 | ENSGALP00000032532 | ENSGALP00000066452 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.959 |
CYP17A1 | DHRS11 | ENSGALP00000032532 | ENSGALP00000008664 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | 0.791 |
CYP17A1 | HSD17B2 | ENSGALP00000032532 | ENSGALP00000008766 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.955 |
CYP17A1 | HSD17B7 | ENSGALP00000032532 | ENSGALP00000057452 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | Uncharacterized protein. | 0.530 |
CYP17A1 | HSD3B1 | ENSGALP00000032532 | ENSGALP00000070096 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | 3Beta_HSD domain-containing protein. | 0.990 |
CYP17A1 | STAR | ENSGALP00000032532 | ENSGALP00000005119 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). | 0.963 |
CYP19A1 | CYP17A1 | ENSGALP00000066452 | ENSGALP00000032532 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | 0.959 |
CYP19A1 | DHRS11 | ENSGALP00000066452 | ENSGALP00000008664 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | 0.791 |
CYP19A1 | HSD17B12 | ENSGALP00000066452 | ENSGALP00000053945 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.951 |
CYP19A1 | HSD17B2 | ENSGALP00000066452 | ENSGALP00000008766 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.953 |
CYP19A1 | HSD17B7 | ENSGALP00000066452 | ENSGALP00000057452 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Uncharacterized protein. | 0.939 |
CYP19A1 | HSD3B1 | ENSGALP00000066452 | ENSGALP00000070096 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 3Beta_HSD domain-containing protein. | 0.988 |
CYP19A1 | STAR | ENSGALP00000066452 | ENSGALP00000005119 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). | 0.884 |
DHRS11 | CYP17A1 | ENSGALP00000008664 | ENSGALP00000032532 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | 0.791 |
DHRS11 | CYP19A1 | ENSGALP00000008664 | ENSGALP00000066452 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.791 |
DHRS11 | GGNBP2 | ENSGALP00000008664 | ENSGALP00000066168 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | 0.695 |
DHRS11 | GUK1 | ENSGALP00000008664 | ENSGALP00000058895 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Guanylate kinase 1. | 0.809 |
DHRS11 | HSD17B12 | ENSGALP00000008664 | ENSGALP00000053945 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.930 |
DHRS11 | HSD17B2 | ENSGALP00000008664 | ENSGALP00000008766 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.977 |
DHRS11 | HSD17B7 | ENSGALP00000008664 | ENSGALP00000057452 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. | Uncharacterized protein. | 0.968 |