STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BCO1Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. (526 aa)    
Predicted Functional Partners:
ALDH1A1
Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity).
   
 
 0.956
RDH10
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.953
RDH11
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.951
DHRS3
Uncharacterized protein.
   
 
 0.948
ALDH1A3
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 
 0.937
DHRS4
Uncharacterized protein.
     
 0.935
ADH1C
Alcohol dehydrogenase 1.
   
 
 0.932
SDR16C5
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.926
RDH8
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.925
ALDH1A2
Retinal dehydrogenase 2; Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral.
     
 0.924
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.