node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCTN1 | DCTN2 | ENSGALP00000074144 | ENSGALP00000050548 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | 0.999 |
DCTN1 | DYNC1H1 | ENSGALP00000074144 | ENSGALP00000036720 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Dynein cytoplasmic 1 heavy chain 1. | 0.999 |
DCTN1 | DYNC1I2 | ENSGALP00000074144 | ENSGALP00000015531 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | WD_REPEATS_REGION domain-containing protein. | 0.974 |
DCTN1 | NDE1 | ENSGALP00000074144 | ENSGALP00000048047 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle; Belongs to the nudE family. | 0.432 |
DCTN1 | NDEL1 | ENSGALP00000074144 | ENSGALP00000053253 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. | 0.553 |
DCTN1 | NUDC | ENSGALP00000074144 | ENSGALP00000001315 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). | 0.453 |
DCTN1 | PAFAH1B1 | ENSGALP00000074144 | ENSGALP00000009354 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. | 0.944 |
DCTN2 | DCTN1 | ENSGALP00000050548 | ENSGALP00000074144 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.999 |
DCTN2 | DYNC1H1 | ENSGALP00000050548 | ENSGALP00000036720 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | Dynein cytoplasmic 1 heavy chain 1. | 0.989 |
DCTN2 | DYNC1I2 | ENSGALP00000050548 | ENSGALP00000015531 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | WD_REPEATS_REGION domain-containing protein. | 0.966 |
DCTN2 | NDEL1 | ENSGALP00000050548 | ENSGALP00000053253 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. | 0.407 |
DCTN2 | PAFAH1B1 | ENSGALP00000050548 | ENSGALP00000009354 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. | 0.943 |
DYNC1H1 | DCTN1 | ENSGALP00000036720 | ENSGALP00000074144 | Dynein cytoplasmic 1 heavy chain 1. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.999 |
DYNC1H1 | DCTN2 | ENSGALP00000036720 | ENSGALP00000050548 | Dynein cytoplasmic 1 heavy chain 1. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | 0.989 |
DYNC1H1 | DYNC1I2 | ENSGALP00000036720 | ENSGALP00000015531 | Dynein cytoplasmic 1 heavy chain 1. | WD_REPEATS_REGION domain-containing protein. | 0.989 |
DYNC1H1 | NDEL1 | ENSGALP00000036720 | ENSGALP00000053253 | Dynein cytoplasmic 1 heavy chain 1. | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. | 0.626 |
DYNC1H1 | NUDC | ENSGALP00000036720 | ENSGALP00000001315 | Dynein cytoplasmic 1 heavy chain 1. | Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). | 0.744 |
DYNC1H1 | PAFAH1B1 | ENSGALP00000036720 | ENSGALP00000009354 | Dynein cytoplasmic 1 heavy chain 1. | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. | 0.958 |
DYNC1I2 | DCTN1 | ENSGALP00000015531 | ENSGALP00000074144 | WD_REPEATS_REGION domain-containing protein. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation. | 0.974 |
DYNC1I2 | DCTN2 | ENSGALP00000015531 | ENSGALP00000050548 | WD_REPEATS_REGION domain-containing protein. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). | 0.966 |