STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GGA2Uncharacterized protein. (490 aa)    
Predicted Functional Partners:
GGA3
Uncharacterized protein.
   
0.939
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
  
  
0.911
SORL1
Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...]
    
 
 0.906
ENSGALP00000072815
VHS domain-containing protein.
 
      0.896
RABEP1
Uncharacterized protein.
    
 0.841
IGF2R
Fibronectin type-II domain-containing protein.
    
 
 0.711
PLAG1
Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation.
      
 0.707
LARP4
HTH La-type RNA-binding domain-containing protein.
   
  
 0.673
CCN3
CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.
      
 0.665
PAK6
Protein kinase domain-containing protein.
      
 0.642
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.