STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)    
Predicted Functional Partners:
CD40
Uncharacterized protein.
   
 0.999
CD4
Uncharacterized protein.
   
 
 0.978
ICOS
IGv domain-containing protein.
  
  
 0.967
CD80
Uncharacterized protein.
   
 
 0.948
CD86
Uncharacterized protein.
   
  
 0.948
TNFSF13B
TNF family B cell activation factor; Belongs to the tumor necrosis factor family.
   
 
 0.933
CD8A-2
Ig-like domain-containing protein.
   
  
 0.884
CD8A-3
Ig-like domain-containing protein.
   
  
 0.872
IL4
Interleukin 4.
      
 0.855
CTLA4
Cytotoxic T-lymphocyte-associated protein 4.
   
  
 0.854
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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