| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PIAS1 | PIAS2 | ENSGALP00000012927 | ENSGALP00000049443 | Uncharacterized protein. | Uncharacterized protein. | 0.656 |
| PIAS1 | RANGAP1 | ENSGALP00000012927 | ENSGALP00000019492 | Uncharacterized protein. | RanGAP1_C domain-containing protein. | 0.416 |
| PIAS1 | SAE1 | ENSGALP00000012927 | ENSGALP00000070956 | Uncharacterized protein. | SUMO1 activating enzyme subunit 1. | 0.861 |
| PIAS1 | SUMO1 | ENSGALP00000012927 | ENSGALP00000069231 | Uncharacterized protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.996 |
| PIAS1 | SUMO2 | ENSGALP00000012927 | ENSGALP00000012928 | Uncharacterized protein. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.886 |
| PIAS1 | UBA2 | ENSGALP00000012927 | ENSGALP00000008003 | Uncharacterized protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.733 |
| PIAS1 | UBE2I | ENSGALP00000012927 | ENSGALP00000010363 | Uncharacterized protein. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.996 |
| PIAS2 | PIAS1 | ENSGALP00000049443 | ENSGALP00000012927 | Uncharacterized protein. | Uncharacterized protein. | 0.656 |
| PIAS2 | SAE1 | ENSGALP00000049443 | ENSGALP00000070956 | Uncharacterized protein. | SUMO1 activating enzyme subunit 1. | 0.755 |
| PIAS2 | SUMO1 | ENSGALP00000049443 | ENSGALP00000069231 | Uncharacterized protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.996 |
| PIAS2 | SUMO2 | ENSGALP00000049443 | ENSGALP00000012928 | Uncharacterized protein. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.831 |
| PIAS2 | UBA2 | ENSGALP00000049443 | ENSGALP00000008003 | Uncharacterized protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.533 |
| PIAS2 | UBE2I | ENSGALP00000049443 | ENSGALP00000010363 | Uncharacterized protein. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.996 |
| PIAS4 | SAE1 | ENSGALP00000046826 | ENSGALP00000070956 | Protein inhibitor of activated STAT 4. | SUMO1 activating enzyme subunit 1. | 0.755 |
| PIAS4 | SUMO1 | ENSGALP00000046826 | ENSGALP00000069231 | Protein inhibitor of activated STAT 4. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.981 |
| PIAS4 | SUMO2 | ENSGALP00000046826 | ENSGALP00000012928 | Protein inhibitor of activated STAT 4. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.928 |
| PIAS4 | UBA2 | ENSGALP00000046826 | ENSGALP00000008003 | Protein inhibitor of activated STAT 4. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.539 |
| PIAS4 | UBE2I | ENSGALP00000046826 | ENSGALP00000010363 | Protein inhibitor of activated STAT 4. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.995 |
| RAN | RANGAP1 | ENSGALP00000054241 | ENSGALP00000019492 | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] | RanGAP1_C domain-containing protein. | 0.996 |
| RAN | SUMO1 | ENSGALP00000054241 | ENSGALP00000069231 | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.844 |
