node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APRT | GMPR2 | ENSGALP00000044023 | ENSGALP00000043066 | Pribosyltran domain-containing protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.933 |
APRT | GMPS | ENSGALP00000044023 | ENSGALP00000016711 | Pribosyltran domain-containing protein. | Uncharacterized protein. | 0.985 |
APRT | GUK1 | ENSGALP00000044023 | ENSGALP00000058895 | Pribosyltran domain-containing protein. | Guanylate kinase 1. | 0.967 |
APRT | ITPA | ENSGALP00000044023 | ENSGALP00000005130 | Pribosyltran domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.987 |
APRT | PDE6C | ENSGALP00000044023 | ENSGALP00000010688 | Pribosyltran domain-containing protein. | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. | 0.904 |
APRT | PDE6H | ENSGALP00000044023 | ENSGALP00000043463 | Pribosyltran domain-containing protein. | Phosphodiesterase 6 gamma subunit cone form. | 0.900 |
CNGA3 | CNGB3 | ENSGALP00000051385 | ENSGALP00000051823 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. | Cyclic nucleotide gated channel subunit beta 3. | 0.884 |
CNGA3 | GNAT2 | ENSGALP00000051385 | ENSGALP00000058253 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. | Uncharacterized protein. | 0.841 |
CNGA3 | PDE6C | ENSGALP00000051385 | ENSGALP00000010688 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. | 0.924 |
CNGA3 | PDE6H | ENSGALP00000051385 | ENSGALP00000043463 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. | Phosphodiesterase 6 gamma subunit cone form. | 0.786 |
CNGB3 | CNGA3 | ENSGALP00000051823 | ENSGALP00000051385 | Cyclic nucleotide gated channel subunit beta 3. | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. | 0.884 |
CNGB3 | GNAT2 | ENSGALP00000051823 | ENSGALP00000058253 | Cyclic nucleotide gated channel subunit beta 3. | Uncharacterized protein. | 0.871 |
CNGB3 | PDE6C | ENSGALP00000051823 | ENSGALP00000010688 | Cyclic nucleotide gated channel subunit beta 3. | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. | 0.890 |
CNGB3 | PDE6H | ENSGALP00000051823 | ENSGALP00000043463 | Cyclic nucleotide gated channel subunit beta 3. | Phosphodiesterase 6 gamma subunit cone form. | 0.858 |
GMPR2 | APRT | ENSGALP00000043066 | ENSGALP00000044023 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Pribosyltran domain-containing protein. | 0.933 |
GMPR2 | GMPS | ENSGALP00000043066 | ENSGALP00000016711 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Uncharacterized protein. | 0.989 |
GMPR2 | GUK1 | ENSGALP00000043066 | ENSGALP00000058895 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase 1. | 0.914 |
GMPR2 | ITPA | ENSGALP00000043066 | ENSGALP00000005130 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.938 |
GMPR2 | PDE6C | ENSGALP00000043066 | ENSGALP00000010688 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. | 0.908 |
GMPR2 | PDE6H | ENSGALP00000043066 | ENSGALP00000043463 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Phosphodiesterase 6 gamma subunit cone form. | 0.900 |