STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCC1Multidrug resistance-associated protein 1; Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (1524 aa)    
Predicted Functional Partners:
ABCG2
ATP-binding cassette sub-family G member 2.
  
 
 0.866
MARF1
Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity.
      
 0.715
C14H16orf45
BMERB domain-containing protein.
      
 0.586
ABCB1
ATP binding cassette subfamily B member 1.
   
 
0.549
ABCB1-2
Multidrug resistance protein 1.
   
 
0.545
PM5
Uncharacterized protein.
      
 0.524
FOPNL
LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
      
 0.482
SLC46A1
Uncharacterized protein.
      
 0.476
HMGB1
High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucle [...]
   
  
 0.470
ABCG4
ATP binding cassette subfamily G member 4.
  
 
 0.465
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.