Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
P4HA2Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (536 aa)    
Predicted Functional Partners:
PYCR3
Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family.
     
 0.954
P4HB
Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). Also acts a structural subunit o [...]
   
 
 0.938
P4HA1
Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.
  
 
0.928
P4HA3
Prolyl 4-hydroxylase subunit alpha 3.
  
 
0.920
PRODH
Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
   
 
 0.905
PRODH2
Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
   
 
 0.905
FIP1L1
Fip1 domain-containing protein.
    
   0.900
LAP3
CYTOSOL_AP domain-containing protein.
     
 0.900
DAO
D-amino acid oxidase.
     
 0.818
COL3A1
Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.
   
 
 0.784
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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