STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TAOK3Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] (937 aa)    
Predicted Functional Partners:
MAP2K3
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
0.918
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
0.914
TAOK1
TAO kinase 1.
  
  
0.903
ZNF622
Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
   
  
 0.673
PHRF1
Uncharacterized protein.
   
  
 0.641
ENSGALP00000071466
RING-type domain-containing protein.
   
  
 0.641
SH2B3
SH2B adaptor protein 3.
      
 0.630
SPPL3
Signal peptide peptidase like 3.
      
 0.630
APIP
Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
      
 0.630
RAC1
GTPase cRac1A.
    
  0.512
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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