node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APIP | ENSGALP00000071466 | ENSGALP00000054200 | ENSGALP00000071466 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | RING-type domain-containing protein. | 0.623 |
APIP | PHRF1 | ENSGALP00000054200 | ENSGALP00000057828 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | Uncharacterized protein. | 0.623 |
APIP | SH2B3 | ENSGALP00000054200 | ENSGALP00000007323 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | SH2B adaptor protein 3. | 0.630 |
APIP | SPPL3 | ENSGALP00000054200 | ENSGALP00000011293 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | Signal peptide peptidase like 3. | 0.630 |
APIP | TAOK3 | ENSGALP00000054200 | ENSGALP00000069369 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.630 |
ENSGALP00000071466 | APIP | ENSGALP00000071466 | ENSGALP00000054200 | RING-type domain-containing protein. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | 0.623 |
ENSGALP00000071466 | PHRF1 | ENSGALP00000071466 | ENSGALP00000057828 | RING-type domain-containing protein. | Uncharacterized protein. | 0.900 |
ENSGALP00000071466 | SH2B3 | ENSGALP00000071466 | ENSGALP00000007323 | RING-type domain-containing protein. | SH2B adaptor protein 3. | 0.523 |
ENSGALP00000071466 | TAOK3 | ENSGALP00000071466 | ENSGALP00000069369 | RING-type domain-containing protein. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.641 |
MAP2K3 | MAP2K6 | ENSGALP00000050706 | ENSGALP00000064623 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | 0.902 |
MAP2K3 | TAOK1 | ENSGALP00000050706 | ENSGALP00000006481 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | TAO kinase 1. | 0.926 |
MAP2K3 | TAOK3 | ENSGALP00000050706 | ENSGALP00000069369 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.918 |
MAP2K6 | MAP2K3 | ENSGALP00000064623 | ENSGALP00000050706 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.902 |
MAP2K6 | TAOK1 | ENSGALP00000064623 | ENSGALP00000006481 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | TAO kinase 1. | 0.927 |
MAP2K6 | TAOK3 | ENSGALP00000064623 | ENSGALP00000069369 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.914 |
PHRF1 | APIP | ENSGALP00000057828 | ENSGALP00000054200 | Uncharacterized protein. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. | 0.623 |
PHRF1 | ENSGALP00000071466 | ENSGALP00000057828 | ENSGALP00000071466 | Uncharacterized protein. | RING-type domain-containing protein. | 0.900 |
PHRF1 | SH2B3 | ENSGALP00000057828 | ENSGALP00000007323 | Uncharacterized protein. | SH2B adaptor protein 3. | 0.523 |
PHRF1 | TAOK3 | ENSGALP00000057828 | ENSGALP00000069369 | Uncharacterized protein. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.641 |
RAC1 | TAOK3 | ENSGALP00000011538 | ENSGALP00000069369 | GTPase cRac1A. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family [...] | 0.512 |