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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). (405 aa)    
Predicted Functional Partners:
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.948
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
     
 0.932
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
   
 
 0.930
PIK3CG
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
     
 0.921
PIP5K1C
PIPK domain-containing protein.
   
0.920
PIKFYVE
Phosphoinositide kinase, FYVE-type zinc finger containing.
     
0.919
TMEM55A
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
   
 
 0.919
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.918
PIP5K1B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates reorganization of actin filaments (By similarity).
   
 
0.918
MTMR3
Uncharacterized protein.
   
 
 0.917
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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