STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRR5LProline rich 5 like. (366 aa)    
Predicted Functional Partners:
MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1; Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity); Belongs to the SIN1 family.
    
 0.844
MLST8
MTOR associated protein, LST8 homolog.
    
 0.830
MTOR
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.800
PRR5
Uncharacterized protein.
     
0.772
RICTOR
RPTOR independent companion of MTOR complex 2.
    
 0.667
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.
    
 0.588
RPTOR
Regulatory associated protein of MTOR complex 1.
     
 0.586
RBL2
Uncharacterized protein.
    
 
 0.452
RBL1
RB transcriptional corepressor like 1.
    
 
 0.452
RB1
Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...]
    
 
 0.452
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.