Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MAP2K5Uncharacterized protein. (582 aa)    
Predicted Functional Partners:
MAP3K2
Protein kinase domain-containing protein.
  
 
0.994
LOC100858386
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.970
MAP3K3
Mitogen-activated protein kinase kinase kinase 3.
  
 
0.918
LOC420419
Uncharacterized protein.
    
 
 0.895
SQSTM1
Sequestosome 1.
    
 
 0.889
BTBD9
BTB domain-containing protein.
      
 0.761
MAPK3
Mitogen-activated protein kinase.
  
 
0.752
MAP3K4
Mitogen-activated protein kinase kinase kinase 4.
    
 
 0.695
VASH1
Vasohibin 1.
      
 0.669
BRAF
Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
   
 
 0.631
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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