node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IPO13 | KCTD2 | ENSGALP00000050448 | ENSGALP00000012875 | Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | BTB domain-containing protein. | 0.861 |
KCTD2 | IPO13 | ENSGALP00000012875 | ENSGALP00000050448 | BTB domain-containing protein. | Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.861 |
KCTD2 | MRPL50 | ENSGALP00000012875 | ENSGALP00000025009 | BTB domain-containing protein. | 39S ribosomal protein L50, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL50 family. | 0.825 |
KCTD2 | PCNA | ENSGALP00000012875 | ENSGALP00000064149 | BTB domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.853 |
KCTD2 | RANGAP1 | ENSGALP00000012875 | ENSGALP00000019492 | BTB domain-containing protein. | RanGAP1_C domain-containing protein. | 0.868 |
KCTD2 | RNPS1 | ENSGALP00000012875 | ENSGALP00000015093 | BTB domain-containing protein. | RNA binding protein with serine rich domain 1. | 0.839 |
KCTD2 | SAE1 | ENSGALP00000012875 | ENSGALP00000070956 | BTB domain-containing protein. | SUMO1 activating enzyme subunit 1. | 0.891 |
KCTD2 | SRRL | ENSGALP00000012875 | ENSGALP00000004145 | BTB domain-containing protein. | ACT domain-containing protein. | 0.828 |
KCTD2 | SUMO1 | ENSGALP00000012875 | ENSGALP00000069231 | BTB domain-containing protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.869 |
KCTD2 | TARDBP | ENSGALP00000012875 | ENSGALP00000004576 | BTB domain-containing protein. | TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity). | 0.863 |
KCTD2 | UBA2 | ENSGALP00000012875 | ENSGALP00000008003 | BTB domain-containing protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.926 |
MRPL50 | KCTD2 | ENSGALP00000025009 | ENSGALP00000012875 | 39S ribosomal protein L50, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL50 family. | BTB domain-containing protein. | 0.825 |
PCNA | KCTD2 | ENSGALP00000064149 | ENSGALP00000012875 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | BTB domain-containing protein. | 0.853 |
PCNA | SUMO1 | ENSGALP00000064149 | ENSGALP00000069231 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.896 |
RANGAP1 | KCTD2 | ENSGALP00000019492 | ENSGALP00000012875 | RanGAP1_C domain-containing protein. | BTB domain-containing protein. | 0.868 |
RANGAP1 | SAE1 | ENSGALP00000019492 | ENSGALP00000070956 | RanGAP1_C domain-containing protein. | SUMO1 activating enzyme subunit 1. | 0.767 |
RANGAP1 | SUMO1 | ENSGALP00000019492 | ENSGALP00000069231 | RanGAP1_C domain-containing protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.998 |
RANGAP1 | TARDBP | ENSGALP00000019492 | ENSGALP00000004576 | RanGAP1_C domain-containing protein. | TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity). | 0.533 |
RANGAP1 | UBA2 | ENSGALP00000019492 | ENSGALP00000008003 | RanGAP1_C domain-containing protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.678 |
RNPS1 | KCTD2 | ENSGALP00000015093 | ENSGALP00000012875 | RNA binding protein with serine rich domain 1. | BTB domain-containing protein. | 0.839 |