| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH2 | CTNNB1 | ENSGALP00000024371 | ENSGALP00000045406 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). | Uncharacterized protein. | 0.845 |
| CDH2 | PTPN1 | ENSGALP00000024371 | ENSGALP00000012986 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). | 0.875 |
| CDH2 | SRC | ENSGALP00000024371 | ENSGALP00000006117 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.710 |
| CTNNB1 | CDH2 | ENSGALP00000045406 | ENSGALP00000024371 | Uncharacterized protein. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). | 0.845 |
| CTNNB1 | MET | ENSGALP00000045406 | ENSGALP00000054618 | Uncharacterized protein. | Uncharacterized protein. | 0.946 |
| CTNNB1 | PTPN1 | ENSGALP00000045406 | ENSGALP00000012986 | Uncharacterized protein. | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). | 0.921 |
| CTNNB1 | SRC | ENSGALP00000045406 | ENSGALP00000006117 | Uncharacterized protein. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.944 |
| GRB2 | INSR | ENSGALP00000012993 | ENSGALP00000048413 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Tyrosine-protein kinase receptor. | 0.923 |
| GRB2 | IRS1 | ENSGALP00000012993 | ENSGALP00000007937 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Insulin receptor substrate 1. | 0.991 |
| GRB2 | IRS4 | ENSGALP00000012993 | ENSGALP00000013147 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Insulin receptor substrate 4. | 0.975 |
| GRB2 | JAK2 | ENSGALP00000012993 | ENSGALP00000074116 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] | 0.815 |
| GRB2 | MET | ENSGALP00000012993 | ENSGALP00000054618 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Uncharacterized protein. | 0.977 |
| GRB2 | PTPN1 | ENSGALP00000012993 | ENSGALP00000012986 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). | 0.750 |
| GRB2 | SRC | ENSGALP00000012993 | ENSGALP00000006117 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.911 |
| GRB2 | TYK2 | ENSGALP00000012993 | ENSGALP00000053236 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Tyrosine-protein kinase. | 0.666 |
| INSR | GRB2 | ENSGALP00000048413 | ENSGALP00000012993 | Tyrosine-protein kinase receptor. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.923 |
| INSR | IRS1 | ENSGALP00000048413 | ENSGALP00000007937 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 1. | 0.988 |
| INSR | IRS4 | ENSGALP00000048413 | ENSGALP00000013147 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 4. | 0.975 |
| INSR | PTPN1 | ENSGALP00000048413 | ENSGALP00000012986 | Tyrosine-protein kinase receptor. | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). | 0.972 |
| IRS1 | GRB2 | ENSGALP00000007937 | ENSGALP00000012993 | Insulin receptor substrate 1. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.991 |
STRING v12.5 is now available!
