HSPD1 protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP5A1W	ATP5A1Z	ENSGALP00000064282	ENSGALP00000054293	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.901
ATP5A1W	ENSGALP00000051793	ENSGALP00000064282	ENSGALP00000051793	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein.	0.565
ATP5A1W	HSP90AA1	ENSGALP00000064282	ENSGALP00000060285	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.576
ATP5A1W	HSP90AB1	ENSGALP00000064282	ENSGALP00000016523	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Heat shock cognate protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its [...]	0.576
ATP5A1W	HSPA5	ENSGALP00000064282	ENSGALP00000001474	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.565
ATP5A1W	HSPA9	ENSGALP00000064282	ENSGALP00000003717	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family.	0.806
ATP5A1W	HSPD1	ENSGALP00000064282	ENSGALP00000013122	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...]	0.884
ATP5A1W	HSPE1	ENSGALP00000064282	ENSGALP00000064174	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.473
ATP5A1W	TCP1	ENSGALP00000064282	ENSGALP00000060032	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein.	0.430
ATP5A1Z	ATP5A1W	ENSGALP00000054293	ENSGALP00000064282	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.901
ATP5A1Z	ENSGALP00000051793	ENSGALP00000054293	ENSGALP00000051793	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein.	0.565
ATP5A1Z	HSP90AA1	ENSGALP00000054293	ENSGALP00000060285	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.647
ATP5A1Z	HSP90AB1	ENSGALP00000054293	ENSGALP00000016523	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Heat shock cognate protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its [...]	0.628
ATP5A1Z	HSPA5	ENSGALP00000054293	ENSGALP00000001474	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.565
ATP5A1Z	HSPA9	ENSGALP00000054293	ENSGALP00000003717	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family.	0.822
ATP5A1Z	HSPD1	ENSGALP00000054293	ENSGALP00000013122	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...]	0.948
ATP5A1Z	HSPE1	ENSGALP00000054293	ENSGALP00000064174	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.579
ATP5A1Z	TCP1	ENSGALP00000054293	ENSGALP00000060032	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Uncharacterized protein.	0.430
ENSGALP00000051793	ATP5A1W	ENSGALP00000051793	ENSGALP00000064282	Uncharacterized protein.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.565
ENSGALP00000051793	ATP5A1Z	ENSGALP00000051793	ENSGALP00000054293	Uncharacterized protein.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.565