STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FURINTrans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)    
Predicted Functional Partners:
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
  
  
 0.976
ACE2
Angiotensin-converting enzyme.
      
 0.890
TGFB1
Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]
    
 0.871
LOC420160
Uncharacterized protein; Belongs to the peptidase C1 family.
   
 
 0.857
MMP11
Matrix metallopeptidase 11.
   
 0.842
CTSV
Cathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.
   
 
 0.811
FBN1
Fibrillin 1.
   
 
 0.810
FBN2
Fibrillin 2.
   
 
 0.808
TMPRSS4
Uncharacterized protein; Belongs to the peptidase S1 family.
  
  
 0.800
PROC
Uncharacterized protein.
  
 
 0.796
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.