| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADRB2 | GNAI1 | ENSGALP00000048596 | ENSGALP00000044195 | Adrenoceptor beta 2. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.918 |
| ADRB2 | GNB1 | ENSGALP00000048596 | ENSGALP00000039575 | Adrenoceptor beta 2. | WD_REPEATS_REGION domain-containing protein. | 0.760 |
| DRD2 | GNAI1 | ENSGALP00000012625 | ENSGALP00000044195 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.955 |
| DRD2 | GNB1 | ENSGALP00000012625 | ENSGALP00000039575 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. | WD_REPEATS_REGION domain-containing protein. | 0.642 |
| GNAI1 | ADRB2 | ENSGALP00000044195 | ENSGALP00000048596 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | Adrenoceptor beta 2. | 0.918 |
| GNAI1 | DRD2 | ENSGALP00000044195 | ENSGALP00000012625 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. | 0.955 |
| GNAI1 | GNB1 | ENSGALP00000044195 | ENSGALP00000039575 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | WD_REPEATS_REGION domain-containing protein. | 0.948 |
| GNAI1 | LPAR1 | ENSGALP00000044195 | ENSGALP00000025320 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.950 |
| GNAI1 | MAPK3 | ENSGALP00000044195 | ENSGALP00000002278 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | Mitogen-activated protein kinase. | 0.936 |
| GNAI1 | NRAS | ENSGALP00000044195 | ENSGALP00000043468 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.916 |
| GNAI1 | PIK3R5 | ENSGALP00000044195 | ENSGALP00000038543 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. | 0.932 |
| GNAI1 | PLCB1 | ENSGALP00000044195 | ENSGALP00000045835 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.934 |
| GNAI1 | PLCB2 | ENSGALP00000044195 | ENSGALP00000050925 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.916 |
| GNAI1 | PLCB4 | ENSGALP00000044195 | ENSGALP00000067730 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.932 |
| GNB1 | ADRB2 | ENSGALP00000039575 | ENSGALP00000048596 | WD_REPEATS_REGION domain-containing protein. | Adrenoceptor beta 2. | 0.760 |
| GNB1 | DRD2 | ENSGALP00000039575 | ENSGALP00000012625 | WD_REPEATS_REGION domain-containing protein. | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. | 0.642 |
| GNB1 | GNAI1 | ENSGALP00000039575 | ENSGALP00000044195 | WD_REPEATS_REGION domain-containing protein. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.948 |
| GNB1 | LPAR1 | ENSGALP00000039575 | ENSGALP00000025320 | WD_REPEATS_REGION domain-containing protein. | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.651 |
| GNB1 | MAPK3 | ENSGALP00000039575 | ENSGALP00000002278 | WD_REPEATS_REGION domain-containing protein. | Mitogen-activated protein kinase. | 0.401 |
| GNB1 | NRAS | ENSGALP00000039575 | ENSGALP00000043468 | WD_REPEATS_REGION domain-containing protein. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.696 |
STRING v12.5 is now available!
