APMAP protein (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

APMAP

Adipocyte plasma membrane-associated protein. (415 aa)

Predicted Functional Partners:

EXOSC10

0.912

B9D2

0.912

IMP3

0.893

FDXACB1

0.876

TSFM

0.794

MTIF2

0.786

EIF5B

0.783

RPL23A

0.775

PDCD11

0.760

AUH

0.760

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APMAP	AUH	ENSGALP00000014075	ENSGALP00000069282	Adipocyte plasma membrane-associated protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.760
APMAP	B9D2	ENSGALP00000014075	ENSGALP00000072648	Adipocyte plasma membrane-associated protein.	RNase_PH domain-containing protein.	0.912
APMAP	EIF5B	ENSGALP00000014075	ENSGALP00000027015	Adipocyte plasma membrane-associated protein.	Tr-type G domain-containing protein.	0.783
APMAP	EXOSC10	ENSGALP00000014075	ENSGALP00000004870	Adipocyte plasma membrane-associated protein.	HRDC domain-containing protein.	0.912
APMAP	FDXACB1	ENSGALP00000014075	ENSGALP00000012923	Adipocyte plasma membrane-associated protein.	Ferredoxin-fold anticodon binding domain containing 1.	0.876
APMAP	IMP3	ENSGALP00000014075	ENSGALP00000070825	Adipocyte plasma membrane-associated protein.	IMP U3 small nucleolar ribonucleoprotein 3.	0.893
APMAP	MTIF2	ENSGALP00000014075	ENSGALP00000056360	Adipocyte plasma membrane-associated protein.	Tr-type G domain-containing protein.	0.786
APMAP	PDCD11	ENSGALP00000014075	ENSGALP00000054340	Adipocyte plasma membrane-associated protein.	Programmed cell death 11.	0.760
APMAP	RPL23A	ENSGALP00000014075	ENSGALP00000006308	Adipocyte plasma membrane-associated protein.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.775
APMAP	TSFM	ENSGALP00000014075	ENSGALP00000069225	Adipocyte plasma membrane-associated protein.	EF_TS domain-containing protein.	0.794
AUH	APMAP	ENSGALP00000069282	ENSGALP00000014075	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Adipocyte plasma membrane-associated protein.	0.760
AUH	IMP3	ENSGALP00000069282	ENSGALP00000070825	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	IMP U3 small nucleolar ribonucleoprotein 3.	0.482
B9D2	APMAP	ENSGALP00000072648	ENSGALP00000014075	RNase_PH domain-containing protein.	Adipocyte plasma membrane-associated protein.	0.912
B9D2	EXOSC10	ENSGALP00000072648	ENSGALP00000004870	RNase_PH domain-containing protein.	HRDC domain-containing protein.	0.999
B9D2	IMP3	ENSGALP00000072648	ENSGALP00000070825	RNase_PH domain-containing protein.	IMP U3 small nucleolar ribonucleoprotein 3.	0.889
B9D2	PDCD11	ENSGALP00000072648	ENSGALP00000054340	RNase_PH domain-containing protein.	Programmed cell death 11.	0.748
EIF5B	APMAP	ENSGALP00000027015	ENSGALP00000014075	Tr-type G domain-containing protein.	Adipocyte plasma membrane-associated protein.	0.783
EIF5B	IMP3	ENSGALP00000027015	ENSGALP00000070825	Tr-type G domain-containing protein.	IMP U3 small nucleolar ribonucleoprotein 3.	0.983
EIF5B	PDCD11	ENSGALP00000027015	ENSGALP00000054340	Tr-type G domain-containing protein.	Programmed cell death 11.	0.775
EIF5B	RPL23A	ENSGALP00000027015	ENSGALP00000006308	Tr-type G domain-containing protein.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.976

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.891

expected number of edges:

10

PPI enrichment p-value:

0.0588

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

2 of 5

2.4

0.91

0.0316

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

2 of 14

1.95

0.88

0.0308

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1526

AMP-binding, conserved site, and Thioredoxin

2 of 5

2.4

0.8

0.0487

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009326

Formate dehydrogenase complex

2 of 3

2.62

1.33

0.0064

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01568

Molydopterin dinucleotide binding domain

2 of 2

2.8

1.28

0.0082

PF00384

Molybdopterin oxidoreductase

2 of 2

2.8

1.28

0.0082

PF00501

AMP-binding enzyme

2 of 11

2.06

0.86

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006963

Molybdopterin oxidoreductase, 4Fe-4S domain

2 of 2

2.8

1.03

0.0212

IPR006657

Molybdopterin dinucleotide-binding domain

2 of 2

2.8

1.03

0.0212

IPR006656

Molybdopterin oxidoreductase

2 of 2

2.8

1.03

0.0212

IPR041575

NADH-rubredoxin oxidoreductase, C-terminal

2 of 3

2.62

1.02

0.0212

IPR009010

Aspartate decarboxylase-like domain superfamily

2 of 3

2.62

1.02

0.0212

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00926

Molybdopterin oxidoreductase Fe4S4 domain

2 of 2

2.8

1.69

0.0017

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