node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DICER1 | PDCD4 | ENSGALP00000036777 | ENSGALP00000069409 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.555 |
DICER1 | PTEN | ENSGALP00000036777 | ENSGALP00000005747 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.664 |
E2F5 | PDCD4 | ENSGALP00000047710 | ENSGALP00000069409 | E2F_TDP domain-containing protein. | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.543 |
EIF4A2 | EIF4B | ENSGALP00000057000 | ENSGALP00000062150 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | Eukaryotic translation initiation factor 4B. | 0.976 |
EIF4A2 | PDCD4 | ENSGALP00000057000 | ENSGALP00000069409 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.781 |
EIF4B | EIF4A2 | ENSGALP00000062150 | ENSGALP00000057000 | Eukaryotic translation initiation factor 4B. | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.976 |
EIF4B | PDCD4 | ENSGALP00000062150 | ENSGALP00000069409 | Eukaryotic translation initiation factor 4B. | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.650 |
ENSGALP00000069790 | PDCD4 | ENSGALP00000069790 | ENSGALP00000069409 | Protein kinase domain-containing protein. | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.534 |
PDCD1 | PDCD4 | ENSGALP00000064012 | ENSGALP00000069409 | Ig-like domain-containing protein. | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | 0.662 |
PDCD1 | PDCD6 | ENSGALP00000064012 | ENSGALP00000021816 | Ig-like domain-containing protein. | Programmed cell death 6. | 0.683 |
PDCD1 | PDCD7 | ENSGALP00000064012 | ENSGALP00000033158 | Ig-like domain-containing protein. | Programmed cell death 7. | 0.665 |
PDCD4 | DICER1 | ENSGALP00000069409 | ENSGALP00000036777 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | 0.555 |
PDCD4 | E2F5 | ENSGALP00000069409 | ENSGALP00000047710 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | E2F_TDP domain-containing protein. | 0.543 |
PDCD4 | EIF4A2 | ENSGALP00000069409 | ENSGALP00000057000 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.781 |
PDCD4 | EIF4B | ENSGALP00000069409 | ENSGALP00000062150 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Eukaryotic translation initiation factor 4B. | 0.650 |
PDCD4 | ENSGALP00000069790 | ENSGALP00000069409 | ENSGALP00000069790 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Protein kinase domain-containing protein. | 0.534 |
PDCD4 | PDCD1 | ENSGALP00000069409 | ENSGALP00000064012 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Ig-like domain-containing protein. | 0.662 |
PDCD4 | PDCD6 | ENSGALP00000069409 | ENSGALP00000021816 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Programmed cell death 6. | 0.690 |
PDCD4 | PDCD7 | ENSGALP00000069409 | ENSGALP00000033158 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Programmed cell death 7. | 0.617 |
PDCD4 | PTEN | ENSGALP00000069409 | ENSGALP00000005747 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.755 |