node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSGALP00000055831 | ENSGALP00000053792 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Citrate synthase, mitochondrial. | 0.997 |
ACLY | FH | ENSGALP00000055831 | ENSGALP00000021472 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Uncharacterized protein. | 0.778 |
ACLY | GOT1 | ENSGALP00000055831 | ENSGALP00000012086 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.849 |
ACLY | GOT2 | ENSGALP00000055831 | ENSGALP00000060782 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.852 |
ACLY | MDH1 | ENSGALP00000055831 | ENSGALP00000014374 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Malate dehydrogenase, cytoplasmic. | 0.972 |
ACLY | MDH2 | ENSGALP00000055831 | ENSGALP00000003012 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Malate dehydrogenase. | 0.981 |
ACLY | ME1 | ENSGALP00000055831 | ENSGALP00000071743 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Malic enzyme. | 0.762 |
ACLY | ME3 | ENSGALP00000055831 | ENSGALP00000068461 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Malic enzyme; Belongs to the malic enzymes family. | 0.805 |
ACLY | PC | ENSGALP00000055831 | ENSGALP00000068177 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Lipoyl-binding domain-containing protein. | 0.963 |
ACLY | PCK2 | ENSGALP00000055831 | ENSGALP00000071013 | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. | 0.955 |
CS | ACLY | ENSGALP00000053792 | ENSGALP00000055831 | Citrate synthase, mitochondrial. | ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. | 0.997 |
CS | FH | ENSGALP00000053792 | ENSGALP00000021472 | Citrate synthase, mitochondrial. | Uncharacterized protein. | 0.985 |
CS | GOT1 | ENSGALP00000053792 | ENSGALP00000012086 | Citrate synthase, mitochondrial. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.944 |
CS | GOT2 | ENSGALP00000053792 | ENSGALP00000060782 | Citrate synthase, mitochondrial. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.953 |
CS | MDH1 | ENSGALP00000053792 | ENSGALP00000014374 | Citrate synthase, mitochondrial. | Malate dehydrogenase, cytoplasmic. | 0.989 |
CS | MDH2 | ENSGALP00000053792 | ENSGALP00000003012 | Citrate synthase, mitochondrial. | Malate dehydrogenase. | 0.999 |
CS | ME1 | ENSGALP00000053792 | ENSGALP00000071743 | Citrate synthase, mitochondrial. | Malic enzyme. | 0.985 |
CS | ME3 | ENSGALP00000053792 | ENSGALP00000068461 | Citrate synthase, mitochondrial. | Malic enzyme; Belongs to the malic enzymes family. | 0.983 |
CS | PC | ENSGALP00000053792 | ENSGALP00000068177 | Citrate synthase, mitochondrial. | Lipoyl-binding domain-containing protein. | 0.979 |
CS | PCK2 | ENSGALP00000053792 | ENSGALP00000071013 | Citrate synthase, mitochondrial. | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. | 0.964 |